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Vitamin D supplementation may help patients with migraines, according to RCT

Posted on: December 7, 2015   by  Amber Tovey


A recent randomized controlled trial (RCT) discovered that vitamin D supplementation reduced the frequency of migraines.

Neurogenic inflammation plays a significant role in the pathogenesis of migraines. Since vitamin D possesses anti-inflammatory properties, researchers have hypothesized that vitamin D supplementation would improve frequency and symptom severity of migraines via reduced inflammation.

Last month, a different RCT investigated the effects of vitamin D supplementation on migraines. The study found that vitamin D supplementation reduced the frequency, but not severity or symptoms of migraines. However, the intervention group received both simvastatin (a statin used to lower cholesterol) and vitamin D, making it impossible to differentiate whether the benefits were attributed to vitamin D or simvastatin.

In the current RCT, 65 patients who suffer from migraines were randomly divided into the intervention and control groups. The intervention group received a weekly vitamin D supplement of 50,000 IU for 10 weeks, while the control group received a weekly placebo pill for 10 weeks.

The research took place in Iran, a country with an extremely high prevalence of vitamin D deficiency, estimated at nearly 75%. The patients’ age varied from 10 to 61 years.

Vitamin D levels were measured at baseline and after supplementation. At baseline, 15.4%, 66.1% and 18.5% of patients were vitamin D deficient (< 12 ng/ml), insufficient (12-30 ng/ml) and sufficient ( > 30 ng/ml), respectively. Migraine severity was determined using the Visual Analog Scale, a measurement instrument used for subjective characteristics that cannot be directly measured, such as pain. A neurologist recorded the mean duration and frequency of headache attacks. The researchers calculated a score they called “headache diary result” (HDR) by multiplying the duration of headache with the frequency of headaches.

Here is what the researchers found from the data recorded:

  • There was no significant difference between severity and duration of headache attacks among the two groups.
  • The average frequency of migraine was lower in the intervention group compared to the control group, but this difference was only marginally significant (P = 0.06).
  • Mean HDR was significantly lower in the intervention group compared to the control group.

The researchers concluded,

“In summary, the present study showed that the effect of vitamin D supplementation on the frequency and headaches diary result can be effective, although the effect on migraine frequency was at significance threshold.”

The study presented interesting findings in support of the hypothesis that vitamin D supplementation may help those who suffer from migraines. However, the study had a rather small sample size. Future RCTs should enroll more participants and use daily dosing rather than weekly dosing to provide more insight on the role of vitamin D in the treatment of migraines.


Tovey, A. & Cannell, J. Vitamin D supplementation may help patients with migraines, according to RCTThe Vitamin D Council Blog & Newsletter, November, 2015.


Mottaghi T., et al. Effect of Vitamin D supplementation on symptoms and C-reactive protein in migraine patients. Journal of Research in Medical Sciences, 2015.

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