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Vitamin D status increased with probiotic, says new randomized controlled trial

Posted on: May 15, 2013   by  John Cannell, MD


We all have an intestinal microbiome. It is the totality of the intestinal microflora living in our intestines, such as bacteria, viruses, fungi and other living creatures. It also includes the genetic composition of the microflora and their interactions with the body, especially the immune system. It has been shown that microbiome serves important functions in immunity, inflammatory signaling, metabolism, and maintenance of normal barrier functions.

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4 Responses to Vitamin D status increased with probiotic, says new randomized controlled trial

  1. [email protected]

    This studied people who had excessive cholesterol. No indication if there would be benefit of any probiotic for other people.

  2. Brandowbarry

    the probiotic group increased 25(OH)D by 25% (6 ng/ml) over the time of the 13 week intervention period, which was a significant mean change relative to placebo (p= .003), which increased by 22.4% (7 ng/ml). Probiotic; 6ng/ml X 4 = 24ng/ml at T = 0? Placibo; 7 ng/ml X 4.464 = 31.2 ng/ml at T = 0?
    Both increased > 20%. Determining the causitive factor(s) for this might be more significant than the (p = 0.003) mean change. ie. – was 22.4% of the probiotic sample change due to the same non-probiotic factor(s) as in the placibo group? Is the remaining 2.6% delta really significant?

    • Brant Cebulla

      Brandowbarry, by significant, I’m assuming you’re asking about clinical significance, not statistical significance. Is it clinically significant? In my opinion, no. But it might strike the fancy of researchers interested in the topic.


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