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Does vitamin D status impact mortality risk in dialysis patients?

Posted on: March 7, 2018   by  Riley Peterson & John Cannell, MD.


A recent systematic review and meta-analysis discovered that higher vitamin D levels were associated with reduced all-cause and cardiovascular related mortality in dialysis patients.

The researchers performed a literature search to include papers written on the relationship between vitamin D and mortality in dialysis patients. After analysis of the available evidence, the researchers discovered that for every 10 ng/ml (25 nmo/l) increase in vitamin D levels, patients experienced a a 22% decrease in all-cause mortality risk(p < 0.0001) and a 29% decrease in cardiovascular mortality risk (p = 0.004).

The researchers concluded:

“In conclusion, the current systematic review and meta-analysis of observational studies found that higher serum 25(OH)D level was associated with lower all-cause mortality and lower cardiovascular mortality in dialysis patients.”


Zhang, Y. et al. Vitamin D status and mortality risk among patients on dialysis: a systematic review and meta-analysis of observational studies. Nephrology Dialysis Transplantation, 2018.

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