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Vitamin D status associated with disability in MS

Posted on: May 15, 2012   by  Vitamin D Council


According to a 5 year observational study, increased vitamin D status is associated with decreased disability and increased preservation of grey matter in patients with multiple sclerosis.

The researchers assessed vitamin D serum levels, clinical disability, and MRI brain volumes annually in 491 patients with MS.

Dr Ellen Mowry and colleagues found that with every 10ng/ml increase in 25-hydroxyvitamin D level, subsequent normalized grey matter was 7cc higher, and expanded disability status scale (EDSS) scores were 0.05 points lower.

Dr Mowry stated she regularly supplements her patients with vitamin D to raise levels up to a range of 40-60 ng/mL.

Dr Mowry is the lead investigator in a randomized treatment trial which will assess the efficacy of high and low dose vitamin D supplementation on attack rates, changes in brain volume, and appearance of new lesions in patients with relapsing-remitting MS.

We’ll keep you posted on the results of this upcoming study!


Mowry EM, Waubant E, McCulloch CE, Okuda DT, Evangelista AA, Lincoln RR, Gourraud PA, Nrenneman D, Owen MC, Qualley P, Bucci M, Hauser SL, Pelletier D. Vitamin D status predicts new brain MRI activity in multiple sclerosis. Annals of Neurology. May 2012.

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