Most people will develop a type of wart at some point in their lives. Plantar warts are one of the most serious forms of warts, occurring on the bottom of the feet. It is caused by an infection with human papillomavirus (HPV) in the outer layer of skin on the feet. Not everyone who comes into contact with HPV develops plantar warts; it’s highly dependent on the individual’s immune system response.
Most plantar warts are resistant to treatment. Since vitamin D helps the immune system function optimally, researchers recently proposed the hypothesis that intralesional vitamin D injections would be an effective treatment for plantar warts. Intralesional injections refer to the delivery of a medication or nutrient directly into a specific skin lesion to treat local tissues.
Twenty patients with at least one plantar wart received a vitamin D injection following a local anasthetic. The treatment was administered in four-week intervals. A total of 16 out of 20 patients showed complete resolution of warts, and 1 patient showed partial resolution.
The researchers concluded,
“Intralesional vitamin D3 may be an effective treatment option for warts.”