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Vitamin D levels associated with severity of non-alcoholic fatty liver disease, according to recent study

Posted on: May 11, 2014   by  Will Hunter


A cross-sectional study observing overweight and obese children with non-alcoholic fatty liver disease has found that vitamin D levels may be associated with the severity of the disease.

The study, published in European Journal of Endocrinology, found an association between vitamin D levels and the presence of nonalcoholic steatohepatitis and liver fibrosis in patients with non-alcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) is caused by fat being deposited into the liver not due to excessive alcohol use. Non-alcoholic steatohepatitis (NASH) is the most extreme form of non-alcoholic fatty liver disease. Fibrosis is the formation of excess connective tissue that damages the function of the tissue or organ it is formed in. Scarring is a form of fibrosis that occurs in response to injury.

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1 Response to Vitamin D levels associated with severity of non-alcoholic fatty liver disease, according to recent study

  1. Davidclements

    I am wondering whether liver disease leads to a deficiency in 25-hydroxylation of vitamin D. I have a patient with NAFLD and very low 25-OH D levels despite supplementation. I suspect that if I could measure cholecalciferol and cholecalciferol sulfate in this patient those levels would be adequate. Is anyone out there investigating this? Alternatively, is there a supplement of calcidiol available for those with liver disease? (I have not been able to find this).

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