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Vitamin D deficiency may reduce pregnancy chances during fertility therapy

Posted on: July 24, 2014   by  Vitamin D Council


Researchers recently found that low vitamin D levels may reduce pregnancy chances in women undergoing in-vitro fertilization.

In-vitro fertilization (IVF) is a form of assisted reproductive technology that involves fertilizing a women’s egg outside of her body. It is used to help women become pregnant who are having trouble conceiving or aren’t able to conceive a child through normal reproduction.

Researchers have found vitamin D receptors in the female reproductive system, suggesting that vitamin D binds to these receptors and plays a role in this system.

While previous studies have examined vitamin D’s effect on the reproductive system in certain conditions, there hasn’t been much research looking at vitamin D’s role in IVFor assisted reproduction.

A research team that included researchers from Belgium and Peru recently conducted a study to determine if vitamin D was related to rates of achieving pregnancy among women undergoing IVF.

They recruited 368 infertile women who underwent IVF and a single embryo transfer. A single embryo transfer is the process of artificially placing a woman’s embryo after IVF into the uterus.

The researchers then measured the vitamin D levels of these women 7 days prior of the embryo transfer.

They found that rate of achieved pregnancies was 45% among women with vitamin D levels less than 20 ng/ml compared to 54% among women with levels greater than 20 ng/ml.

After controlling for potential factors that may affect pregnancy rates, the researchers found that vitamin D deficiency was independently related to fewer clinical pregnancies.

“Vitamin D deficiency impairs pregnancy rates in women undergoing single blastocyst transfer,” the researchers stated.

The research team called for additional studies to examine if vitamin D status measured prior to IVF affects rates of pregnancies.


Polyzos, N. et al. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Human Reproduction, 2014.

1 Response to Vitamin D deficiency may reduce pregnancy chances during fertility therapy

  1. Rita and Misty

    Here’s an interesting project that was launched in San Diego by GrassrootsHealth It’s called: Vitamin D Action Needed Now to Protect Pregnancies and Babies. Something like this can be easily replicated in your home town. Well, perhaps not easily… 😉 But all worthwhile achievements tend to be difficult….right? (a glimpse into my personality 🙂 )


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