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Vitamin D deficiency found extremely common among children with nephrotic syndrome

Posted on: February 3, 2015   by  Vitamin D Council


Recently published research has discovered a high prevalence of vitamin D deficiency among children at diagnosis of nephrotic syndrome.

Nephrotic syndrome (NS) is characterized by excess protein in the urine. NS is usually caused by damage to small blood vessels in your kidneys that filter waste and excess water from your blood. This results in swelling due to excess fluid retention.

Children with NS are treated with high doses of prednisone, which helps to decrease inflammation. However, side effects of the drug include bone loss.

Since vitamin D has been shown to reduce inflammation and strengthen bones, researchers wanted to determine the prevalence of vitamin D deficiency among children with NS.

The researchers found that 13 of the 14 children examined were considered vitamin D deficiency, and 12 had moderate or severe vitamin D deficiency.

The researchers concluded,

“We suggest that vitamin D status in children with NS be measured routinely at the time of diagnosis so that an individual treatment strategy for vitamin D deficiency can be given. Further studies are needed to evaluate the effect of such treatment.”


Nielsen CA, Jensen JE & Cortes D. Vitamin D status is insufficient in the majority of children at diagnosis of nephrotic syndrome. Danish Medical Journal, 2015.

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