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Vitamin D: Breast cancer treatment effect?

Posted on: September 17, 2012   by  John Cannell, MD


In a remarkable paper from Stanford University, Dr Swami and company, working under senior author Professor David Feldman, discovered that vitamin D has a treatment effect in mice that have surgically implanted inflammatory breast tumors. This is the same famous Dr Feldman who edits the textbook, Vitamin D.

Swami S, Krishnan AV, Wang JY, Jensen K, Horst R, Albertelli MA, Feldman D. Dietary vitamin D₃ and 1,25-dihydroxyvitamin D₃ (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer. Endocrinology. 2012 Jun;153(6):2576-87.

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6 Responses to Vitamin D: Breast cancer treatment effect?

  1. [email protected]

    Lots of vitamin D works well for cancers, etc.– provided cofactors are adjusted

    There have been several clinical trials reports of problems using vitamin D as a monotherapy. Vitamin D increases the bio-availability of Calcium. Most people now lack the Vitamin K2 needed to put the excess Calcium created by the vitamin D into bones. Instead, the excess Calcium is deposited elsewhere in the body, in places such as arterial walls and breasts. People taking more than about 3,000 IU of vitamin D daily should really try to balance their cofactors.

    Brief cofactor summary:

    – reduce Calcium < 500 mg daily,

    – increase Magnesium to 500 mg daily,

    – take Vitamin K2 – 100 mg daily.

    Details about cofactors: http://is.gd/cofactors

    It describes several more and provides many low cost options for getting the cofactors

    The Vitamin D Council described cofactors in 2011


    101 vitamin D intervention trials added in just the first 7 months of 2012.

    I am unaware of any ongoing trial which balances more than one cofactor.

    Almost all use monotherapy (half of the subjects take vitamin D and see what happens)

    List of the 101 new vitamin D intervention trials: http://is.gd/intervention

    Which includes 8 reasons why many of the trials will not be successful.

  2. Ian

    How does vitamin K2 affect these results. Would a human be able to tolerate a higher dose of vitamin D if the vitamin K levels were also increased. I note the IOM has not set an UL for the menaquinones. So it may be possible to take as much as 25mg/Kg.

  3. [email protected]

    Failed to mention in previous comment

    There are many ways to optimize vitamin D response to a dose

    Some of the optimization methods MAY not increase Calcium problems

    Increase Vitamin K2

    Take your vitamin D with the largest meal of the day:

    Increase the monosaturated fats in your diet (e.g. almonds)

    Increase Magnesium

    Increase Boron

    Increase Cholesterol in your diet – for absorption through your gut

    Increase Omega-3 which may increase by 60% the ACTIVE form, not the tested form

    Avoid having too much vitamin A

    Those people with poor guts should use a more bio-available form

    Details at: http://is.gd/2xvitd

    By the way: most of the cofactors are available combined in low cost liquid or pill form

    Details: http://is.gd/cofactors

  4. [email protected]

    [email protected]–thanks for your last post on co-factors. Such good information. Perhaps if following this protocol, it isn’t even necessary (or beneficial) to consume a calcium supplement? It is easy to get under 500 mg calcium daily from food selections.

    Again, really appreciate your post.

    Rita Umile

  5. rcessna

    Dr. Cannell,

    Went to the Dr. today. Chest X-Ray, blood work.

    Asked him to check my Vitamin D3 level.

    Last time, 10 months or so, my level was 100 ng/ml.

    He asked if I knew that there was an increased risk for CHD with anything

    over 50. My research has not shown this to be true.

    What’s your take on this.


    Ray Cessna

  6. Ron Carmichael

    @Rcessna: ANYTIME a practitioner provides you with a statement as fact, like “there was an increased risk for CHD with anything over 50”, it is perfectly reasonable to ask for the reference so that you can study up on it – ask in a respectful and polite but firm way, of course, you are in a professional relationship and you after all, want to know as much as you can about your condition,right? 🙂 And when he gives you that study, put it up here where Dr. J can review it…..

    My other curiosity is with his value of “50”, wherein I would confirm he is working from a lab test 25(OH)D results, AND that he is aware that women lactating postpartum will not pass vitamin D to the infant when the level is NOT in the 40 to 50 range, for example..and that mother nature puts many indigenous groups, as well as laborers, life guards, well into their 50 ng/ml ranges and what does he think about the lack of CHD epidemics in these groups.. Doctors are incredibly stressed for time, and may sometimes see a synopsis written by a drug company hostile, or take away the wrong conclusion from a non-medical journal “news” article. Many times an editor for a tabloid or magazine will distort the content with a completely inane headline that is the only thing many people will read. Regardless, work with your doctor to educate both him and yourself, and perhaps you can benefit more than just you two. (if it improves his standard of practice with other patients….)

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