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Vitamin D and DNA repair

Posted on: January 16, 2012   by  John Cannell, MD


Below is a paper that challenges my comprehension of biology. Unbelievably, scientists have identified at least five genes that code for DNA repair proteins, whose only job is to fix your DNA when it is broken. Professor James Fleet of Purdue University and his colleagues authored an excellent detailed review of how vitamin D helps prevent cancer and he almost offhandedly mentioned DNA repair as one of vitamin D’s mechanisms of action in cancer. Remember, vitamin D has as many mechanisms of action as genes it regulates.

Fleet JC, Desmet M, Johnson R, Li Y. Vitamin D and cancer: a review of molecular mechanisms. Biochem J. 2012 Jan 1;441(1):61-76.

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5 Responses to Vitamin D and DNA repair

  1. PeterVermont

    DNA repair usually works by correcting one strand to match another template strand. It would not fix an inherited mutation where no correct template strand exists

  2. mdweck

    Hi DR Cannell
    My friend’s 17 year old daughter has Lafora progressive myoclonus epilepsy, a genetic disorder with no known cure.
    Do you think vitamin D supplementation might slow the progression of this terrible disease?

  3. John

    hi Dr
    There is something to this b/c my wife has (had?) some type of error on her X chromosomes affecting the development of boys as evidenced by several miscarriages. However, after her D levels were raised for a few years we did infact have a perfectly healthy boy. Go D!

  4. [email protected]

    Excellent. My wife’s 17 years old student’s oncologist is having her take 10,000 IU a day. She has a stage 4 cancer (digestive region) and last time I saw her, she looked healthy to me. She is still undergoing chemotherapy, I think 3rd or 4th round so far with a few more to go. No hair loss or anything. You couldn’t tell at all by looking at her.

    I recently found out from a friend who told me that his friend’s doctor is having the patient take vitamin D supplement but my friend doesn’t know all the details. So that’s two doctors in Texas so far…

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