Recently read of a promising study using a vitamin d analog, calcipitriol, for pancreatic cancer. What can you tell me about calcipitriol and can the general public utilize it as a supplement.

Asked by  mmoddey2 on January 14, 2015

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  • mmoddey2
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     mmoddey2 on

    See title

    Answered by  mmoddey2 on

  • IAW
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     IAW on

    Calcipitriol is a synthetic Vitamin D. Why not just use regular Vitamin D3?

    Answered by  IAW on

    • mmoddey2
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       mmoddey2 on

      the article, written by mara H sherman in CELL just 5 months ago, clearly stated that the benefit was only seen with vitamin D analoogues. specifically Calcipitriol. As a family member of someone diagnosed with pancreatic cancer, I am understandably very interested in this finding. Problem being, all analogues need a prescription, and doctors are unwilling to step outside their “safe zone” when asked about it. There seems to be a variance on the article, one stating calcipitriol (commonly prescribed as a cream for psoriasis) and others referring to paricalcitol, a drug used for reducing parathyroid hormone. Obviously, this issue will be pushed with the treating oncologist, however given that the end result of using either of these analogues is increased vitamin D, Its very difficult to sit idle knowing that such a promising variant of vitamin D is available but unnatainable. The full, unlocked research can be found here:http://www.housemajority.org/wp-content/uploads/2014/10/47-Vitamin_D_Receptor-Mediated_Stromal_Reprogramming_Suppresses_Pancreatitis_and_Enhances_Pancriatic_Cancer_Therapy.pdf

      Answered by  mmoddey2 on

  • IAW
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     IAW on

    I would keep checking back for awhile to see if anyone else responds later with any helpful information.
    The Vitamin D Council originally stated when they reviewed the study that “It is also important to reiterate that the vitamin D they used in this study was a synthetic derivative of vitamin D.” “This research does not suggest that normal vitamin D supplementation has the same effect, and the researchers even examined this and found that standard supplements did not work.” Since I have not read the actually study yet, I do not know how they came to the conclusion that standard supplements did not work.
    I am sorry about your family member and their diagnosis! Do you know what there present Vitamin D level (25OHD) is?
    You may find Harry’s website helpful too for information if you have not already found it http://www.vitamindwiki.com

    Answered by  IAW on

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