My doctor, a well respected endocrinologist says that is is vital when checking Vitamin D3 levels to run both the 25-Hydroxy blood test as well as Vit d, 1,25. My 25 Hydoxy test indicates a low level of 27.5 on recent blood work but for 1,25 shows a level of 72.1 My Dr. says the 72.1 is what is actually being absorbed and is a bit high and has suggested I cut my supplementation down from 4,000 to 2,000. IU's Do you agree with her assessment? Thanks.

Asked by  wexworld on November 2, 2014

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  • wexworld
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     wexworld on

    See title

    Answered by  wexworld on

  • IAW
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     IAW on

    http://onlinelibrary.wiley.com/doi/10.1359/jbmr.070716/pdf states the following:
    “This indicates that serum 25(OH)D is the measurement of choice to diagnose vitamin D deficiency and to assess vitamin D status. On the other side, serum 1,25(OH)2D is not suitable to assess vitamin D status because it is kept within reference limits as long as possible by hormonal mechanisms,
    especially PTH for stimulation and serum calcium and phosphate for suppression”.
    The above is also what Dr. Cannell has said in the past on the Vitamin D website. So I believe the answer would be no they do not agree.

    Answered by  IAW on

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