I've recently discovered that while my 25-Hydroxy-D is normal (29.6 ng/mL), my calcitriol 1,25-D is extremely high (140 pg/mL). I am not hypercalcaemic, and my parathyroid levels are normal. I've seen 2 endocrinologists, and both are puzzled by what could be causing this. Interestingly enough, my 9 year old daughter seems to have the same problem. Her 25-H-D is normal, and her 1,25 D is 130 pg/mL. We're having her dad tested to see if this is genetic or environmental. Is there any disorder or possible answer to why this could be happening? The endocrinologist had spoken of a genetic enzyme mutation that may cause it, but wasn't sure of the specifics. I'd love to get some insight on how this could be happening.

Asked by  britsherman88167600 on February 12, 2015

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  • britsherman88167600
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     britsherman88167600 on

    See title

    Answered by  britsherman88167600 on

  • IAW
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     IAW on

    So here is a very good article to read at http://www.aafp.org/afp/recommendations/viewRecommendation.htm?recommendationId=140.
    There is nothing unusual, environmental or genetic about this. The simple fact is that when Vitamin D stores are low (25-Hydroxy levels), then 1,25 D goes “high”. The next thing you will say is but my 25 OHD levels are “normal”. Well I am not sure what the low end of the range is at your lab but mine is 30ng/ml. So you are just slightly below. The reason the Vitamin D Council exists is because those levels are too low to be healthy. That is why we promote having a 25-OHD level of 50ng/ml or above.
    (Maybe you would like to copy the article and give it to the Endocrinologists!)

    Answered by  IAW on

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