Asked by shailew66333300 on April 24, 2017
I have started taking 5000 iu. vitamin D3. I have stopped taking antipsychotic – Risperidone 0.5 mg, given to me for depression, as it has terrible side effects. More than 2 weeks since I stopped so facing withdrawal effects. Depression is their but at a reduced intensity. Should I increase the Vitamin D3 dosage?
Shalie I am so sorry it took so long to fix the Q and A. Apparently they were in the middle of other “site” fixes when it went down and had to wait until they were done.
Your level of 22ng/ml is very low. Believe it or not it is probably what is causing your depression. We here at the VDC recommend a minimum level of 50ng/ml to be healthy.
The “official” upper limit to take is 10,000iu a day. It is very important to read http://www.vitamindcouncil.org/about-vitamin-d/vitamin-d-and-other-vitamins-and-minerals/.
You certainly can take the 10,000iu and see if you feel better faster. Sometimes Vitamin D can cause symptoms because it can then cause a depletion in vitamins or minerals. The most common one is low magnesium. Magnesium deficiency symptoms can be
•Irritability or anxiety, Nausea, Headaches, Insomnia, Fatigue, Muscle cramps/twitching, Weakness and constipation. So be careful you do not confuse the “withdrawl” with something like that.
You can ask me as many questions as you need to and let me know how you are doing. If you have any problems, come back and tell me.
I mostly aim to be conservative but if the 10,000iu is not enough then you may have to take more and that is not a bad thing. Eventually you may be able to take a maintenance dosage of 5000iu but you may need more. If you feel you need more than 10,000iu come back and tell me first!
Hope you feel well soon!
I read these posts with interest…I was diagnosed with a severe vitamin D deficiency and since starting supplements my symptoms have improve significantly. However, as time has progressed I have found myself needing to take more and more vitamin D to maintain my progress. I read about magnesium and i’m interested to try it, although I can’t find anything about vitamin D actually depleting magnesium levels in research articles or on any of the reputable sites on vitamin D. Do you have a source?
Tom my source of information is Dr. Cannell. If he says to do something, I heed his warnings. I have read this website from its beginning. (Actually once I found it, I went back and read all 4-5 years I had missed.) Since the focus here is Vitamin D, they chose not to go into great detail here, just warn that there is a good chance you may be deficient with today’s present diets.
I think your best bet would be to look up http://drcarolyndean.com/magnesium_miracle/ she is the guru on magnesium. She has a book and in the book maybe she sites studies that you could look up. Have you tried Pub Med?
As for “I have found myself needing to take more and more vitamin D to maintain my progress”. What most people do not know is that you probably need more Vitamin D up front and maybe less later. Usually we promote take 5000iu a day and eventually it will get you where you need to be. If you are trying to correct a deficiency you should usually start at 8000-10,000iu a day, retest in 8 weeks and if you have made it to at least 50ng/ml, then try a maintenance dosage of 5000iu. BUT should symptoms reappear then you just need to take more. I will warn you, taking the higher amounts just may make a vitamin or mineral deficiency appear. Usually it’s magnesium BUT I just had someone and it was B2. In general I have also found people tell me when diagnosed with a D deficiency they also have a B12 deficiency.
Thank you so much for your help. It will highly be useful.
Hi IAW, as you pointed out I am suffering from Magnesium deficiency. I feel very uneasy, nausea, unable to sleep, anxiety & headache. 3 days back I took a multivitamin with 50 mg Magnesium Oxide & I felt better. next day I continued with the multivitamin & I was OK, day before I didn’t take the multivitamin & I had severe problem so I took one. But then body started demanding more, yesterday I had to take twice. Today I bought Magnesium Hydroxide 200 mg and took it twice. I am feeling much better, symptoms have gone down. I am already taking Vitamin D 10000 iu. My confusion is there are different types of Magnesium supplements, which one should I take & how much? Thanks.
I don’t blame you for being confused. The “magnesium in aspartate, citrate, lactate, and chloride forms is absorbed more completely and is more bioavailable than magnesium oxide and magnesium sulfate” and also add the hydroxide to that.
A general rule is to think anything ending in “ate” like citrate is good. Your body can absorb these better and therefore get “better use out of them”.
I would still take the multi each day!! As for the extra magnesium try 500mg more. (Don’t even count what is in the multi.) I try and split mine up during the day with my meals. So for example if you found a “citrate” with 200mg in each pill then either take one with each meal (total 600mg per day) OR at least two meals for a total of 400mg. You will have to judge by your symptoms, how much you need.(Down the road you may need less.) The worse thing that can happen is if you get too much, you will probably get loose bowels and then you need to cut back on the amount you take. Sometimes people take magnesium before bed because it helps them sleep.
Somehow I feel am I falling short in magnesium. My backache has gone but my nausea & slight depression with anxiety keeps coming back though it is less than earlier. After decades of depression & anxiety I do feel a bit hopeful of new therapy. I read a lot positive about this therapy & I am eager to get well. Interestingly, since I started taking Vitamin D3 & now Magnesium, Antidepressant seems to have no effect on me but I am scared to drop them, I take Sertraline 100mg. & also Clonazepam 0.5mg. I am caught between 2 therapies & want to hang in there so I am chattering a bit. Other than nausea I am fine. Unfortunately my Doctor is least helpful with my new therapy. How long will it take for my Vitamin D3 level to come above 50 ng/ml now that I have started taking 10000 iu and what do you mean by I will need less of Magnesium down the road? When will that happen? By the way I am 50 years old male & short in height 5 feet 3 inches, very optimistic person and depression has taught me to have lots of patience. Please give your valuable suggestions. Hope I am not troubling you. Thanks a lot.
At this point I do want you to know I am not a doctor or scientist. When you originally said “I have stopped taking antipsychotic – Risperidone 0.5 mg, given to me for depression”, I was a little anxious. Since you had already stopped it, I did not comment on this. What you will have to understand is I cannot comment on the other drugs (stopping) them because I am not comfortable doing so. I do understand that you are probably not getting much help from your doctor. If someone tells me they are taking an antidepressant I try and warn them of the following if it is a “Reuptake Inhibitor (SSRI)”. If the Vitamin D corrects the depression problem, then I do not know if it is possible to then end up with “serotonin syndrome”. If you do not know this is “high levels of serotonin in the body”. Symptoms include “agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, and fainting”. As you can see agitation and nausea are on the list. So do they belong to the lack of magnesium or serotonin syndrome?
Sometimes I have suggested that people stop the Vitamin D and take several days of magnesium and then try again. I am NOTsuggesting that you do this. You could go at this slower and take the 5000iu for several weeks to a month (I am guessing on the time frame) and then increase it later. Maybe it would lesson some of the symptoms.
Weight can factor in with how much Vitamin D a person needs also. So although 10,000iu is not really a big amount, it can be for some people.
Your levels should increase within two months. Please do not equate the level with feeling well that could be two different things and we will have to wait and see. For example if you took 10,000 for two months, retested and now had a level of 70ng/ml but you still felt slightly depressed, I might suggest trying a little more Vitamin D to see if it helps or not.
One person said they absolutely needed the supplemental Vitamin K to make the D work for their depression. So take the co-factors listed at the link dated May 5th seriously, in your diet or in supplements.
What I meant about the magnesium is this. For years and years you have been “D” deficient. Now you have given yourself a reasonable amount and now your body can do all sorts of good things with it. BUT it does need those co-factors so “my thoughts” are it may cause a “temporary shortage” or a “short term” increased need. After things “level” out maybe you will not need to take as much and still be OK. Only time will tell and this, “I think”, goes for other vitamins and minerals.
If “chattering” helps, it is OK by me!
I will keep in mind about Serotonin Syndrome. Your empathy + knowledge is more important to me it doesn’t matter whether you are a Doctor or not. And Doctors are human too & they have their own protocols. Over a period, patient tends to know more about his body than Doctor especially if he is observant. I will know whether a particular antidepressant suits me or not after 1 or 2 days but Doctor will wait till it fails. I stopped Respiridone because of terrible side effects and after a period of Vitamin D3 I felt I don’t need it. Maybe I am right, it is long time since I stopped & I am OK. Side effects of Respiridone made me put on 10 Kgs of weight & my reflexes became sluggish. I was uncomfortable balancing my two-wheeler especially on tough roads & heavy traffic. I am a fitness lover & was unable to enjoy work outs. Could not be regular. Now my reflexes have returned to normal.
Coming to Serotonin Syndrome, I don’t think I have it as of now. I agree with your suggestion of reducing my dosage to 5000 iu & then increasing after few weeks, this body is unable to handle 10000 iu I think. Initially it could not handle even 5000 iu I had reduced to 2000 iu when it fell short I increased to 3k iu then 4k & 5k. My panic attacks have gone. Today was a better day, no severe nausea. I started taking Vitamin K 40 mcg. My body reacted very positively to Vitamin D3 after the first dose, I felt great after many years as if free of depression. Maybe once my D level comes up I will feel better. I am going to change my Doctor. I will take his guidance for tapering Sertraline. Will also inform him about Vitamin D. Please give your valuable suggestions. Thanks.
I tapered off Sertraline. As of now, for now last 26 days I am not on any Antidepressants or Anti-psychotics. I did experienced lot of withdrawal symptoms but I am OK now. I am do not rule out periodic withdrawal symptoms but believe it will become lesser in intensity. I got the reports of Vit D lev tests, it is 42.15 ng/ml. This is after 2 months of Vitamin D3 10000 iu. I tested Magnesium levels too, they are OK. 1.85 mg.dl. At the moment, I do am facing withdrawal symptoms but they are expected otherwise no panic attacks absolutely. When my withdrawal symptoms increased in previous 2 days I took 2000 iu of D3 extra, don’t that was the cause but I woke up next day, improved. What is your suggestion for me? Which dosage should I continue & what Vitamin D level should I achieve & maintain? What maintenance dosage? It is truly rebirth for me at the age of 50. When people go through midlife crisis I feel rejuvenated. Thanks.
I am so glad you are doing better and feeling better!!!
I was really surprised that your level was not “higher” than what it ended up being on 10,000iu a day for two months. So to answer one of your questions, do NOT take less than 10,000iu a day. Now considering the extra 2000iu the other day, helped with your symptoms, I think you should try an experiment and take more. I will leave how much up to you. You could take 15,000iu a day and see what happens or take 12,000iu a day and see what happens. Maybe either one will get rid of all of your symptoms once and for all. Maybe your “withdraw” symptoms are not withdraw symptoms and you just need more D. (My “guess” would be that 12 will get you to a level of 60 and 15 will probably get you to 80.) More importantly than the level is, does it make you feel better?
Also note that, for example, in times of severe emotional stress or you hurt yourself or you have surgery, you may need more Vitamin D than what you normally take.
Also do not stop taking the magnesium. Blood tests for minerals only measure the 1-2 percent that is found in your blood stream. It does not measure what is in your cells or your bodily stores. So you can “pass” the test and still be deficient.
Let me know what you think!
I have started taking 12000 iu of Vitamin D3. I was feeling alright then I took Alcohol, a good amount, on Sunday, since then I am feeling severe Nausea & anxiety. Still not recovered. What is your suggestion? I shouldn’t have taken alcohol. Will reaching higher levels of Vitamin D help me in stabilizing? Is higher dosage of Vitamin D3 cause some side-effects such as nausea? Could it be because of combined effect higher dosage of Vitamin D3 + high alcohol? What should I do?
Hi. I don’t drink much, once or twice in a month. For last 1 year, whenever I have a drink I suffer anxiety & depression after some time. This was not happening prior to that. What cold be the cause? Could it happen if Vitamin D level in the body becomes too low? Now, from morning, I have started taking Ayurvedic medicine for Liver which has reduced my nausea. Though I also have allergic sneezing & cold, it comes during monsoon. Thanks.
If you think the 12,000 iu is making things worse, than go back to 10,000 iu.
Sometimes if people take too much Vitamin D, even very small amounts, they can get hypercalcemia. The symptoms of hypercalcemia include: feeling sick or being sick, poor appetite or loss of appetite, feeling very thirsty, passing urine often, constipation or diarrhea, abdominal pain, muscle weakness or pain, feeling confused, feeling tired and bone pain. I really do “not” think you have this but a simple way to check is a blood test for calcium levels.
Here is my guess. Now that you are taking Vitamin D, Vitamin D by itself uses a lot of magnesium. A quick check of the internet says that alcohol makes magnesium levels lower. Your symptoms “still point to not enough magnesium”. How much are you taking at this point?
What kind of K are you taking, K1 or K2?
You asked “Does withdrawal from antidepressant makes brain use up more Vitamin D”? I don’t know. Your level “has risen” and that is a good thing. There are probably three reasons it is not higher, One if you are overweight, two maybe your genetic makeup just needs more or three the Vitamin D is still trying to “repair things” and is therefore still using up a lot. (The allergies may actually being using up the Vitamin D.)
Nausea and anxiety usually indicates low magnesium. Depression can be low calcium or potassium.
I too think it is not hypercalcemia. I am taking Magnesium Glycinate 400 mg & Vitamin K2 MK7 40 mcg. These could be Withdrawal symptoms also. It is 1 month since I stopped Sertraline & Sertraline remains in body for 3/4 weeks & withdrawal symptoms may last upto 3 months. Though I will get my Potassium, Calcium & Magnesium checked to be on safe side.
Again when it comes to any mineral a blood test is not the best. Even if it comes up “in the range”, it can be well worth trying a supplement anyway.
Is the 400mg of magnesium all in one pill or capsule? If it is then you could try 800mg but if it is too much then you will get loose bowels. If it is really 200mg in a pill or capsule and you take two then maybe try 3.
You could try doubling the Mk7 to 80mcg a day and see if that changes anything.
Your right it could still be withdrawal symptoms.
I am taking pill of Magnesium Glycinate 400 mg, seeing some gradual improvement over last 2 days. I wanted to know what harm Hypercalcemia can do? If I do reduce the dosage of Vitamin D3 to 10000 iu how will that affect my recovery? Will it take longer? If yes, how long to reach 70 level? If I continue with 12000 iu will my body settle down after few days? Will my body adjust with 12000 iu? I would love to continue with 12000 iu though if it helps early recovery. My nausea, depression and anxiey have gone down but are still there & that is a worry but I can hold on. Please suggest.
Hi, I took Vitamin K2 80 mcg today but degree of improvement is same like yesterday. I have less of Hypercalcemia symptoms. My symptoms are anxiety, depression but not prolonged, goes away after a while & nausea but my appetite is intact. There is frequent urination today but that could also be because of anxiety, no unusual thirst, no confusion though only little worry because of anxiety, no feeling tired or muscle weakness, I know symptoms differ from person to person.
It is my understanding that if you were to have hypercalcemia, you would get most of those symptoms. I really do not think you have this. If you did then you would have to stop the Vitamin D and stay out of the sunshine until your calcium levels returned to “normal”. Then you and a doctor would have to decide if you just took too much Vitamin D and adjust the amount taken or decide if you cannot take it at all because any amount gives you hypercalcemia. Also it only hurts you if you continue to have it for a long time not a short time.
Does the anxiety and depression come within a few hours after ingesting the Vitamin D or does it just come and go at anytime?
You said “I am taking pill of Magnesium Glycinate 400 mg, seeing some gradual improvement over last 2 days”. Does this mean you were not taking it at all or that you “increased the amount taken”?
I think sometimes some people just have to take it a little slower for their recovery. It is great that you can take the 10,000iu so if you have “less symptoms” on that amount, then just take that amount for now. I still think this is caused by “low magnesium”.
The other thing you may want to consider is probiotics and see if that helps the stomach issues.
My stomach is not good for quite some time now. That is expected though if you are stopping antidepressants. I have pain in the stomach too but not constant. Sometimes it occurs. I agree I was fine with 10000 iu & I was taking 200 mg of Magnesium and it was fine now as I increased to 12000 iu I increased Magnesiu to 400 mg. I will of course feel sick due to nausea & anxiety which are the main symptoms now. Depression is not their so much. No tiredness or muscular pain as such though sometimes there is pain in the lower back which is not new though. Inspite of nausea my appetite is intact but bowel movement is not good. I have to go several times. Urination is fine. Now only thing possible, as you said, is Magnesium going down. I am testing Calcium & Magnesium tomorrow though you said they are not good indicators. Just to see. I think I will revert back to 10000 iu. It is fine if it takes longer to raise D level.
I think it is third, Vitamin D3 is still repairing so D level not increasing fast enough. I gained weight after I started taking Antipsychotics & Antidepressants especially antipsychotics. I think my body must be in a mess now. Will take some time to recover. I used to go cycling, around 8 km in the morning stopped after monsoon started. Will continue once we get dry spell.
My Magnesium 2 mg/dl & Calcium 9.34 mg/dl values both are within range as per test. Now I have Nausea, Anxiety & Stomach problem, most probably these are withdrawal symptoms. They do not increase or decrease with intake of supplements, they follow their own path. They surely have gone down since they initially started last week but still are good enough to be troublesome. Last night Nausea was bad. I think I should have waited for D levels to rise before stopping my psychiatric medicines. Anyway now I will wait for this to pass. Does Coenzyme Q10 good for me?
You said “since they initially started last week” the “Nausea, Anxiety & Stomach problem”. When exactly did you stop biking because of the monsoons? Was it is the last two weeks or more?
Here is a very good article and they talk about CoQ10 at http://www.optimallivingdynamics.com/blog/7-important-nutrients-depleted-by-psychiatric-drugs-antidepressants-antipsychotics-stimulants-benzodiazepines-induced-guide-vitamins-medications.
I stopped biking for more than 4 weeks back. Unfortunately. I was doing well. I will restart as soon as possible. The good thing is symptoms are going down & I have not reduced Vitamin D3 to 10000 iu still am taking 12000 iu. Thanks for the article, I will go through it.
Sorry sometimes I have to keep asking questions because of information someone like you gives. Sometimes it is not until there is a back and forth do I then “gleen” (get) more important information.
Even though you “biked” in the morning, it was still adding some Vitamin D to your level of 42ng/ml. The best time for Vitamin D production from sunshine is 10 AM to 2 PM BUT this does not mean you do not make Vitamin D at any other times.
What I think happened is when you had to stop biking, your levels probably went lower,hence why you have some symptoms again or recently. The “biking sunshine” was giving you just enough more to make things better and when that stopped you regressed somewhat.
So if you can take the 12,000iu and you are sure it is not causing the issues and may even be making them better, than you may want to consider taking 15,000iu a day and see what happens.
Before you ask, 15,000iu will not hurt you!
Sure I will take 15000 iu. I am feeling better gradually. I went through article and I completely agree with the author. Antidepressants & Antipsychotics do imbalance of vitamins & mineral in your body which creates different symptoms then originally what anxiety & depression alone did. I have ordered for Q10, Probiotics & Melatonin, B12 is easily available here. Soon I will start taking them. I am sure it will help me. In fact D3 alone helped me, this will improve further.
Having problem. Tried Q & A earlier but was not working. I took Probiotic & Q10 on Saturday 29th July & it did not suit me at all, later I realized that it was Probiotic which did not suit me. I too it for 2 days & on 3rd I had sever stomach ache. It was unbearable & I also had fever. Went to the Doctor who gave me antibiotics. Even while taking antibiotics till 3rd day I had terrible stomach ache & till 4th day I had fever. I finished my five day course of antibiotics but still feeling weak, depressed & bitterness in mouth, nausea. My last dose of antibiotics was on Sunday morning but still feeling the effect. What could possibly have had happened & what should I do? I am still taking Vitamin D3 12000 iu, Magnesium, Vitamin K2 & Multivitamin tablet which has B vitamins.
Probiotics should not do that. The only thing I can assume is that there was something in there that should not have been in there and therefore the company that made them are not a reputable company.
I thought you were going to try 15,000iu a day?
It sounds to me like the clonazepam is causing the nausea and maybe even the depression?
I agree, Probiotics shouldn’t do that, it could be some content in it did not suit me. I was going to start D3 15000 iu but then this happened. I was waiting for Vitamin D3 which I had ordered, it has not come yet. Anyway I have started 15000 iu from today. I will stop Clonazapam 0.5mg and take Melatonin 5 mg meanwhile, will it help? Could, stomach infection, have affected my Vitamin D levels? During that period & with Antibiotics killing all good bacteria also must have affected gut’s ability to absorb nutrients. And I am still not out of Antidepressant withdrawal period of at least 90 days. (have completed 50 days) I am sorry I think too much but that’s what mental illness does to you. Good thing is my gut is back to normal. There is no IBS. What is the maximum D3 one can take in a day? Is it safe to take Melatonin? The amount of Vitamins that I am taking, is there any precaution I need to take?
Make sure you keep taking the multi, the K2 and magnesium and try the 15,000iu.
If you really had an infection, then yes you may have used up some of the Vitamin D to fight that.
Why are you taking or want to take the melatonin for? I seem to recall some of those medications could reduce COQ10 levels but I do not remember anything about melatonin.
You said your “gut” is back to normal so does that mean you have nausea or not?
I am not sure it is a good idea to stop the Clonazapam? If you do that right now will it cause “more” withdrawl symptoms?
On July 19th I listed the symptoms of hypercalcemia. Usually a person has to take 40,000iu a day for several months before it “might” cause hypercalcemia. So at 15,000iu you should be fine but just keep the symptoms in mind as you go along.
Melatonin is mentioned in that article but if not required, I will keep it on hold. I will continue with Clonazepam as of now as D level increases it will be easier to stop it. Gut is fine because after long time I am able to pass motion normally, frequency wise, 2 times & at the most 3 & there is no bloating. Nausea, I don’t consider as part of gut, more to do with anxiety & depression. Though I have nausea I have not thrown up for ages. Today nausea was not there but I also increased D3 to 15000 iu & it helped me. Depression & anxiety was low too & for short duration of time. Feeling better.
I am glad the D is helping you.
To be honest you may need even more than 15,000iu a day but I try and be cautious. I would rather not cause someone to have hypercalcemia if I can avoid it.
Let me know how you feel in two weeks on the 15,000iu!
As my gut is becoming normal my depression is gong down. In my current episode of Depression which started in late 2014 but I started taking antideressants from March 2015, I was on Fludac 60 mg from then till June 2016 & also antipsychotic. Till Dec 2015 I was not feeling good so Doctor changed antipsychotic, I was put on Risperidone 0.5 mg, I started feeling better, my gut was OK. In June I had severe attack of some sorts. I was severely anxious, depression, was having continuous panic attacks, nights were horrible. Doctor said Fludac has stopped working for me so for instant recovery he gave me Pramipexole 0.25 mg twice a day. (Since then, the attack of sorts, I am having problem with the gut. Secondly my depression has become dependent on what I eat or drink, otherwise it was not like that earlier. Now change in gut flora would cause me depression. Alcohol started affecting my gut & so my depression.) After 2 months he stopped Pramipexole & switched to Paroxetine, my antipsychotics remained the same throughout. After 3-4 months of Paroxetine, it turned out, it did not work for me so Doctor switched to Sertraline 100 till I stopped it nearly 2 months back. What my query is, why gut is getting affected now? Probably that attack which I experienced last year, could be, drop in the level of Vitamin D, could be, because my teeth had also become painful then. I saw improvement after taking Vitamin D3, my depression also went down but my gut problem remains. The problem is when I take antibiotics or alcohol or such which can affect my gut can cause me depression which goes away when gut becomes normal. So depression has switched from brain to gut. I read that 90% serotonin is produced in gut but I did not feel this way a year back. Hope this goes away when my D level rises. Also when my immunity against depression develops, i.e. remission of some sorts.
I will try not to aggravate my gut for next 4 months. I am taking Vitamin D3 15000 iu but I read in one of the links you gave that it should not have Olive oil but this one has, unfortunately I read it now. I got this from US because it was much cheaper than in India, with 15000 i it will last me for 4 months.
Read this first https://www.ncbi.nlm.nih.gov/pubmed/27515213. Then see “how much” of each of the B vitamins are contained in your multi and how that compares to how much they used in the study.
Not sure if your “gut” bacteria is so “borderline” at the moment that certain things are going to upset the balance. You said “I did not feel this way a year back.” So maybe the Vitamin D is making you better in a lot of respects BUT at the same time causing a shortage in something because it is missing a “raw material”.
I think you should keep in mind that you were taking a lot of different medications and that you have come a long way from where you started. So be patient.
I really doubt you want to try another probiotic at the moment but if you change your mind in the future you may want to try https://www.greenvits.eu/products/bio-tech-lacto-pectin-probiotic-100-capsules-tiny-soft-and-easy-to-swallow. You do not have to buy them from this vitamin shop BUT the brand (BioTech) is a very reputable business and it is contains “no dairy, egg, fish, shellfish, nuts, wheat, gluten, soy, sugar, yeast, artificial preservatives or colors.”
100 mg, it is much higher than dailyy requirement. My tablet contains less. Also it shows Calcium Pantothenate & not Pantothenic Acid, is that fine? Should I take tablet containing B100?
The study says 100mg of all B vitamins except 100MCG of B12 and biotin and 400MCG of folate) (Some are mg and some are mcg.)
A B complex vitamin usually delivers eight of the (following) B vitamins:
B1 (thiamine), (100mg for the study)
B2 (riboflavin), (100mg for the study)
B3 (niacin), (100mg for the study)
B5 (pantothenic acid), (Calcium Pantothenate is also B5)
B6 (pyridoxine), (100mg for the study)
B7 (biotin), (100 “mcg” for the study)
B9 (folic acid), (400 “mcg” for the study)
B12 (cobalamin). (100 “mcg” for the study)
“Should I take tablet containing B100?” I think you would have to look for something called a “B complex vitamin” and it should contain all of these on the list above but you need to double check. Each manufacturer probably puts in different amounts so I guess I would look for one that comes close to the totals above INCLUDING what is in your multi OR take the multi PLUS the amounts listed in the study. I know it is over the RDA but RDA amounts are for normal people without health issues. If a medicine or a “health condition” makes you low on any vitamin or mineral, a normal diet will probably never make up for the deficit.
Since you have gut issues maybe also make sure there is not a lot of additives or things that “might” cause you further issues.
I think it is worth a try to see if it helps. If it does then maybe at some point you will not need to take the “extra”.
I ordered one B Complex which is having 50 mg of all Vitamins B only thing is that it has 400 mcg of Folic acid. If I take 2 capsules it will make it 800 mcg, is that OK? Can I split it into twice a day instead of taking at 1 time? What is Activated Charcoal? Will it help me in any way? Going to start cycling again from tomorrow whatever the condition of mind & body.
This is really interesting and I recommend you reading it at https://www.ncbi.nlm.nih.gov/pubmed/15671130. At the end they recommend 800 folate and B12 1 (one) mg. From what I read you would have to take “really high” amounts (15,000mcg) in order to cause an issue.
I think it would be a good idea to split it to twice a day. If you can also not drink alcohol for awhile, that may help. There is a connection to low B Vitamins and alcohol so if you are already borderline low, then maybe just a little alcohol makes things worse.
The following is from https://www.drweil.com/vitamins-supplements-herbs/vitamins/vitamin-b9-folate/.
Are There Any Other Special Considerations With Folic Acid?
The absorption of supplemental folic acid is reduced slightly when taken with food. Folic acid absorption or depletion may occur in those who use alcohol excessively, who use large amounts of antacids, are prescribed antiobiotics, who take aspirin chronically and in large doses, or who take oral contraceptives. In addition, folic acid, when taken along with vitamin B12, may increase the risk of masking an underlying vitamin B12 deficiency. Caution is advised when taking both of these vitamins together.
Before you try anything else, let’s see what the B’s do.
After started taking Viamin B Complex I felt better instantaneously. Initially I took normal B Complex, from yesterday I am taking Vitamin B-100 (B-50 twice a day). Day before I did B Complex test. B5 is in excess but B12 & B3 are at lower side of the normal range. See the report below. How do you read it?
TEST NAME VALUES NORMAL RANGE
VITAMIN B1/THIAMIN LC-MS/MS 3.25 ng/ml 0.5-4.0
VITAMIN B2/RIBOFLAVIN LC-MS/MS 54.19 ng/ml 1.6-68.2
VITAMIN B3/NICOTINIC ACID LC-MS/MS 1.2 ng/ml 0.3-9.8
VITAMIN B5/PANTOTHENIC LC-MS/MS > 200 ng/ml 11-150
VITAMIN B6/P5P LC-MS/MS 30.6 ng/ml 5 – 50
VITAMIN B7/BIOTIN LC-MS/MS 1.36 ng/ml 0.2-3
VITAMIN B9/FOLIC ACID LC-MS/MS 11.15 ng/ml 0.2-20
VITAMIN B-12 C.L.I.A 259 pg/ml 211-911
I feel better when I have a meal rather than empty stomach. Why body has become so sensitive? I know whether it is related but after I went to cycling few days back I felt depressed, this is after gut infection & antibiotics course. These two things really harmed me. Put me back.
Secondly, after feeling better with Vitamin B complex I decided to stop Clonazepm 0.5 mg, from last 3 days I am not taking it, today is 4th day. I am feeling fine now (can again become bad) though I had terrible withdrawal symptoms. I want my body to get rid of these Psy Medicines which affect brain functioning. I read on websites that Vitamin D & B don’t help in withdrawal but these medications affects the nutrients & unless there are enough nutrients you can’t stop meds, it will not work.
Please give your valuable suggestion.
I agree on the B12 and B3. I would say that generally it is probably best to be in the middle to the high end of the ranges. I would also not be afraid to be over the range, if I felt better taking any vitamin. Let me say this though, the B12 levels in many countries “start” (not in the USA or your country) at 500-550. So your B12 level is “low”. That alone can cause many symptoms and three of them being irritability or depression, and anxiety. So what is the total amount of B12 between all of your supplements?
You said “I read on websites that Vitamin D & B don’t help in withdrawal but these medications affects the nutrients & unless there are enough nutrients you can’t stop meds, it will not work.” You are correct! If someone said to me Vitamin D does not help with withdrawal, I would first have to ask them how much they took. I doubt low amounts would do anything. For you I knew we were giving you a reasonable amount (minimum 10-15,000iu) of Vitamin D (not that we cannot go higher) but then I wondered about a shortage in Vitamins.
You said “after I went cycling few days back I felt depressed”. I can only “guess” that the physical exercise lowered either your D levels or it has to do with the low B12. Was that the first and only time you went cycling after being sick?
So if it happens again after cycling, let me know.
If you think you are having withdrawal symptoms, trying taking an extra 5000iu and see what happens. If that doesn’t then try an extra B complex and see if that does anything.
Total amount of Vitamin B12 I take is 100 mcg. Clearly I need higher levels of B12 as I am predisposed to anxiety & depression. Though I am not a meat eater now (not a vegan) I suffered from depression & anxiety even when I was a meat eater around 18 years prior. But this time it is different, earlier I never felt depressed after taking antibiotics or gut infection or taking alcohol or exercise, this started after the attack I suffered 1 year back which probably was due to low Vitamins, nutrient levels which body could no longer manage.
Anyway, yes, I had problem with cycling after gut infection & antibiotics course, earlier in the year, pre-monsoon, it did not happen. I was feeling fine in fact. This time I went twice & then stopped, I will start again after few days.
This episode of depression, no medicines helped, Doctor tried different ones & antidepressant were of very high dosage too. It is only after I started taking Vitamin D3 did I feel like a new person. Because of D3 I could think of & manage stopping 2 medicines & am trying the third one now.
Should I take higher dose of “Vitamin B12 only”, separately? And how much?
Well in that study I wrote about above on August 13, they said one mg and that equals 1000mcg. So I would start with at least 500mcg added to the 100 you already take. I would buy a separate B12 and add it to the complex.
You are a wonderful person with wonderful knowledge. You are an angel for people like me. I must have done something good in past. Interestingly, there is guidance available but somehow people keep missing it or ignoring it.
I found 500 mcg, I will start from today or maybe tomorrow, how long should I take it? As f now I am taking, Vitamin D3 15000 iu, Q10 100 mg, Vitamin B-100, Magnesium 400 mg, Vitamin K2 100 mcg & now Vitamin B12 500 mcg. When should I check Vitamin D Vitamin B12 again?
After the initial acute symptoms of withdrawal which included, anxiety, restlessness, body pain, flu like feeling, nausea & inability to sleep from yesterday I feeling depressed. Depression can be handled during the day but at nights it becomes difficult especially when I am asleep & suddenly wake up with depression. I think B12 500 mcg will help or I will take B3 20000 iu.
Did you mean B3 200 or 20,000?
I am not sure if B12 will be an immediate affect or long term. When you get the B12, maybe you should take 1000mcg for a week and see how you feel. If 1000 has an immediate affect then after a week try 500. If you lose the affect then go back to the 1000. If you could check in in a month, at least to see if it is increasing, that would be good.
I would not bother to check your Vitamin D level right now. Let’s see how you “feel” in another month or two.
Yesterday I had Vitamin B12 (Methylcobalamin) 1000 mcg after lunch (2 pm) but I had terrible experience. Within 2 hours I had tremendous depression symptoms & it was very very bad, so much so that I couldn’t sleep till around 4 in the morning. After I woke up I am still having them but sure they will go away. I took all my regular Vitamins as per schedule but I dare not take the Vitamin B12 even 500 mcg as of now. Could it be due to particular brand or plain Clonazepam withdrawal symptoms? Today is 8th day since my last Clonazepam. Only thing is I didn’t taper, my dose was 0.5 mg anyway, a small one. But I don’t think I should go back to experimenting with tapering. Please guide.
What I think is I should take antidepressant sertraline in small dosage when depressed or anxious for withdrawal of Clonazepam instead of Clonazepam itself. Sertraline is easier to stop. What do you suggest?
Sorry Shailesh I answered this morning but apparently was not logged in and I did not realize it.
I am sorry you had a reaction to the B12. It is the best type to take so I do not think that was the problem. Maybe the extra B12 caused something else to go “low” and hence the reaction.
On August 10th I said “On July 19th I listed the symptoms of hypercalcemia”. “Usually a person has to take 40,000iu a day for several months before it “might” cause hypercalcemia.”
I cannot advise on the antidepressants.
Is the depression only coming at certain times of the day or at anytime?
Yes I felt depressed, there was a panic attack also but not severe after I took Vitamin B12 1000 mcg. Before that I got depressed at anytime. What about if I take Vitamin D3 5000 iu pill whenever I get extreme symptoms?
Earlier some event at home triggered depression, old person in the relation is very sick. Recently I have noticed I get very emotional & sensitive. I cry easily this is Clonazepam withdrawal symptom.
After long time. For me it seemed very long. It is 4 weeks since I stopped Clonazepam & I think worst is over. 4 more weeks & I suppose it will definitely be easily manageable. Previous 4 weeks were very difficult but I have done very well. Definitely Vitamin D helped me. Though worst seems to be over I still need lots of patience to go through next few weeks. It is a long battle sometimes 1 hour at a time. Coming to Vitamin D, when should I have my next test? Since 1 month I started taking 15000 iu & since 20 days I increased it to 20000 iu. Will suddenly reducing or stopping Vitamin D3 harm me? Not that I want to but yesterday I missed a dose & by evening I was having toothache something I suffered when I was deficient in Vitamin D. Does body get used to some amount of Vitamin D especially when I am going through this withdrawal? Does Vitamin D level in the blood & intake of Vitamin D3 dosage affect body differently? I am asking this because when I started taking Vitamin D3 initially with 2000 iu it affected positively right away though my Vitamin D was still low but depression returned after a week of dose of 2000 iu which was insufficient at that time.
I have read a lot about Clonazepam withdrawal & it is very bad. It is one of the Benzo & very difficult to get off.
Hi! I was wondering how you have been feeling.
The easiest way I can say this is if you get “any” symptoms of hypercalcemia and your calcium levels are “high” then you have to stop the Vitamin D until everything returns to normal.
If the higher amounts are helping you, then just keep taking them and do not worry about the “level”.
It is very hard for me to tell if you need a lot of Vitamin D because you are going thru with drawl or maybe your genetic background requires more or maybe you are still repairing a lot of things in your body.
If you skip a dose it should not affect you that fast but who am I to say that it can’t for you or for you at this point in time. Once your body gets Vitamin D it “looks forward” to having it because it needs it. So I think stopping it will cause symptoms to appear fairly quickly.
You probably should have tapered off the Clonazepam would have made it easier for you.
I was going through lots of varied withdrawal symptoms in past 2 months+. I just weathered the storms, symptoms have gone down considerably. There is occasional reaction to some food I take but is nowhere near what I initially experienced. During this period I suffered stomach bug with fever, throat infection, flu but I did not take antibiotics though Doctor prescribed. Got over the sickness without antibiotics is a big achievement & moral booster. I expect some withdrawal symptoms every now & then for sometime, maybe months, this helps in not being unnecessarily worried every time I suffer, helps recovery as worrying worsens the situation. I checked my Vitamin D levels yesterday & it came to 71.34 ng/ml so I think I have done well here. What should I do next? Should I reduce Vitamin D3 dosage? I am taking 20000 iu.
This recovery from anxiety & depression and stopping of 3 types of Psychiatric medicines & now free of any symptoms of disease (withdrawal symptoms are not a disease as I always recover & keep improving over time) is thanks to your guidance. Vitamin D3 has helped me.
I have been thinking about you and wondering how you are doing. I am glad things are going well.
I am surprised that your level is only 71ng/ml taking the 20,000iu and that it did not end up being much higher.There is a lot we do not know about Vitamin D and one of them is some people may need more than the average amount to feel well and you may be one of them. We routinely tell people who have or had “medical conditions” to keep their levels higher at 80ng/ml.
So you may just want to keep taking the 20,000iu a day forever. You could take it 6 more months and retest to see if the level is “staying the same”. I really do not want to see you get sick again!!! If you want you could try reducing it to 17-18,000 iu and see if you can still feel well. If 20,000iu works, then keep taking that. I think if you decrease your amount too much then you might start to fall below 50ng/ml and you do not want to do that!
DO NOT let anyone tell you your level is too high at 70ng/ml and that you need to take less.
You have made my day!!!!
Thank you so much. I am so much obliged to you. You are very kind to me.
I have been taking 20000 IU from 24th August so around 20 days less than 3 months. Could withdrawal symptoms, the drama within, have prevented levels to rise faster? On 15th July it was 41 ng/ml so it took around 10 days short of 4 months to reach 71 ng/ml. As withdrawal symptoms go down could D levels rise faster? I have been in too much stress in recent time last 4 years. I am going to begin meditation to reduce my level of anxiety, if I am sincere it will help me a lot overall. How much level of D is too much for me?
The Vitamin D Council promotes a minimum level of 50ng/ml to be healthy. Some people need higher levels than that to feel well. For Autistic children or people with health issues, than we push that up to 80ng/ml. The official “upper end” in the USA is 100ng/ml. A level starting at 150ng/ml or better may become a problematic. Some people have been recorded with “natural” (only sunshine” levels of 70ng/ml. So you are fine where you are.
“I believe” that stress whether emotional or physical will make you use up more Vitamin D. I do not have any studies to prove this.
So I think you should keep taking the 20,000iu for “several” more months and retest. If your levels have gone significantly higher at that point, then try cutting back the amount you take. (You can always come back and tell me and ask for more advice.) Most importantly if taking less Vitamin D brings back symptoms or you do not feel as well, then take the higher amount. Better to take a higher amount of Vitamin D then “medicine”!
You should read this https://www.vitamindcouncil.org/why-is-vitamin-d-continuing-to-be-measured-in-international-units/.
How are you? Nice to come back here but I wish it was not due to some problem. Anyway, one month back I changed my brand of Vitamin D3, unfortunately it did not suit me or product is not good enough, I started feeling depressed once in 2/3 days so I checked my Vitamin D levels & as I guessed they were coming down, it is 58 ng/ml. I have again ordered my old brand now.
One more worry for me now is, I did many blood tests they were part of profile, some results were worrying.
HOMOCYSTEINE C.L.I.A 43.8 μmol/L Adult > 30
CREATININE – SERUM PHOTOMETRY 1.42 mg/dl 0.6-1.1
ASPARTATE AMINOTRANSFERASE (SGOT ) PHOTOMETRY 40.4 U/l < 37
ALANINE TRANSAMINASE (SGPT) PHOTOMETRY 71.3 U/l 13-40
EST. GLOMERULAR FILTRATION RATE (eGFR) CALCULATED 57 mL/min/1.73 m2
These are out of range tests only. All other tests show normal.
What is your suggestion?
First did there happen to be any “thyroid tests” in the profile for example a TSH test?
Above tests show some kind of liver and kidney dysfunction. (Remember I am not a doctor.) High HOMOCYSTEINE is “associated with low levels of vitamins B6, B12, and folate, as well as renal disease.” Do you know when the last time was that any of these levels were tested and were “normal”?
Hypothyroidism can cause these issues. I would suggest a TSH level, Free T4, Free T3 and antibody testing which includes
Thyroid peroxidase antibody (TPO) and Thyroglobulin antibody (TGAb).
If anyone can establish an autoimmune disease is present, then this might also be a reason for needing higher levels of Vitamin D.
So you need testing and a doctor.
Let me know what happens!
Test for T3, T4 & TSH is also done & it is normal. All above tests wacky results aside there is absolutely no symptoms other than occasional depression. No, I have not done these tests in recent times, maybe in years.
TOTAL TRIIODOTHYRONINE (T3) C.L.I.A 141 ng/dl 60-200
TOTAL THYROXINE (T4) C.L.I.A 9.7 μg/dl 4.5-12
THYROID STIMULATING HORMONE (TSH) C.L.I.A 1.33 μIU/ml 0.3-5.5
Bilirubin, Protein, Albumin, Globulin are normal.
HbAg, ABG are normal.
TOTAL TRIIODOTHYRONINE and TOTAL THYROXINE are not the same as taking “Free” levels in both of the above tests.
You can have a “normal” TSH but have “high” antibody levels.
I don’t know if the medications could have caused this.
Ok. I don’t mean that. There can be many reasons. Firstly I will do a retest after few days. I will also do ‘Free’ as you mentioned. I am perfectly fine, no issues. I have got over seemingly impossible depression, I will get over this.
I have no reason to believe that the 20,000iu of Vitamin D is causing the higher levels. So in other words “keep taking the 20,000iu. For all we know maybe those levels were even higher before taking any Vitamin D and they are now “lower”. (Now that would have been interesting to know.)
More importantly what I was trying to say is if you can rule out autoimmune thyroid, that would be good. For instance, if you did find a high level of antibodies, then that would explain the “higher” levels AND if you had Hashimoto’s, I would then suggest you to take even more Vitamin D then what you are.
That is wonderful to know. Thanks. I will retest though I am not sure of the report. My BUN, Total Protein in blood & Albumin/Globulin ratio is normal & so is BUN/Creatinine ratio. Nor is their major anomaly in Hemogram.
After going through net I have come to conclusion that increase in SGOT, SGPT & Serum Creatinine is basically due to exercise & muscular damage. The above three other than Homocysteine only are elevated. Before the test, last 20 days I was & am doing strenuous exercise, this is new & first time exercise & I have been consistently doing it though there is muscular pain. Interesting all other parameters of Liver Function Test & Kidney Function test are normal. Basically above test which show elevated remain so for at least 7 days after a strenuous exercise & I have been doing non-stop. I am very relieved.
Secondly, depression & anxiety right now is due to stopping Magnesium & Vitamin K2 with Vitamin D3 20000 iu, just being plain lazy in buying them. Rectified now.
How are you? Writing to you after long time. I know whatever help needed is received by me for my condition. I have seen improvement, there is reduction in side effects which was caused by Psychiatric medicines yet depression comes, at times severe and last for shorter while, maybe a day, I have learnt to handle that now but during that time it is horrible though no panic attacks for long time. Now coming to the reason why I am writing to you, I want to know is Vitamin K2 better than K1? Why?
Well I wished you were totally better, that would make me happier.
Here is a really good article about “K” at https://www.vitamindcouncil.org/the-synergistic-relationship-between-vitamin-d-and-vitamin-k/. Please read.
I think the “science” between the two is not conclusive yet. Meaning they may be “equal” in importance.
The K2 gets a lot of recognition on the internet because of a study in rats where it actually reversed Atherosclerosis in the rats. It was pretty impressive.
Are you still taking 20,000iu of Vitamin D? I realize we have had some fairly long conversations above. Did you ever try taking an extra 5000 or 10,000iu when you feel the depression coming on to see if it will make a difference?
I have been in the most difficult phase of my life, unrelated to health or mental illness, therefore I am OK with the current status. It is enough for me that I am not taking those Psychiatric medicines with terrible side effects. I think the withdrawal symptoms may still be on, we never know. I am under tremendous pressure though.
I took only once 5000 iu but don’t remember what happened, the effect. Yes I am still taking Vitamin D3 20000 iu, once I tried to reduce it to 10000 iu dosage but I was not comfortable so I increased it again. Maybe later on, after sometime I will check Vitamin D3 levels and let you know. Yes, we had long conversation which has given tremendous results for me. Yes I also wish for Depression free phase, hope it happens soon. You have always been so kind.
Just so we do not have a misunderstanding. You said “yet depression comes, at times severe and last for shorter while, maybe a day.” Did you ever try taking the 20,000iu and then ADDING another 5000iu on those days that the depression comes again? OR maybe you should try 25,000iu a day and see if that will stop it from coming at all.
Dr. Cannell, the doctor that runs this website one said “Some readers have written that they require 50,000 IU/day to alleviate depressive symptoms, but that should only be done under the care of a knowledgeable physician with frequent 25(OH)D levels, as such doses may cause toxicity.” Maybe you fall into this group!
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