Asked by shailew66333300 on April 24, 2017
I have started taking 5000 iu. vitamin D3. I have stopped taking antipsychotic – Risperidone 0.5 mg, given to me for depression, as it has terrible side effects. More than 2 weeks since I stopped so facing withdrawal effects. Depression is their but at a reduced intensity. Should I increase the Vitamin D3 dosage?
Shalie I am so sorry it took so long to fix the Q and A. Apparently they were in the middle of other “site” fixes when it went down and had to wait until they were done.
Your level of 22ng/ml is very low. Believe it or not it is probably what is causing your depression. We here at the VDC recommend a minimum level of 50ng/ml to be healthy.
The “official” upper limit to take is 10,000iu a day. It is very important to read http://www.vitamindcouncil.org/about-vitamin-d/vitamin-d-and-other-vitamins-and-minerals/.
You certainly can take the 10,000iu and see if you feel better faster. Sometimes Vitamin D can cause symptoms because it can then cause a depletion in vitamins or minerals. The most common one is low magnesium. Magnesium deficiency symptoms can be
•Irritability or anxiety, Nausea, Headaches, Insomnia, Fatigue, Muscle cramps/twitching, Weakness and constipation. So be careful you do not confuse the “withdrawl” with something like that.
You can ask me as many questions as you need to and let me know how you are doing. If you have any problems, come back and tell me.
I mostly aim to be conservative but if the 10,000iu is not enough then you may have to take more and that is not a bad thing. Eventually you may be able to take a maintenance dosage of 5000iu but you may need more. If you feel you need more than 10,000iu come back and tell me first!
Hope you feel well soon!
I read these posts with interest…I was diagnosed with a severe vitamin D deficiency and since starting supplements my symptoms have improve significantly. However, as time has progressed I have found myself needing to take more and more vitamin D to maintain my progress. I read about magnesium and i’m interested to try it, although I can’t find anything about vitamin D actually depleting magnesium levels in research articles or on any of the reputable sites on vitamin D. Do you have a source?
Tom my source of information is Dr. Cannell. If he says to do something, I heed his warnings. I have read this website from its beginning. (Actually once I found it, I went back and read all 4-5 years I had missed.) Since the focus here is Vitamin D, they chose not to go into great detail here, just warn that there is a good chance you may be deficient with today’s present diets.
I think your best bet would be to look up http://drcarolyndean.com/magnesium_miracle/ she is the guru on magnesium. She has a book and in the book maybe she sites studies that you could look up. Have you tried Pub Med?
As for “I have found myself needing to take more and more vitamin D to maintain my progress”. What most people do not know is that you probably need more Vitamin D up front and maybe less later. Usually we promote take 5000iu a day and eventually it will get you where you need to be. If you are trying to correct a deficiency you should usually start at 8000-10,000iu a day, retest in 8 weeks and if you have made it to at least 50ng/ml, then try a maintenance dosage of 5000iu. BUT should symptoms reappear then you just need to take more. I will warn you, taking the higher amounts just may make a vitamin or mineral deficiency appear. Usually it’s magnesium BUT I just had someone and it was B2. In general I have also found people tell me when diagnosed with a D deficiency they also have a B12 deficiency.
Thank you so much for your help. It will highly be useful.
Hi IAW, as you pointed out I am suffering from Magnesium deficiency. I feel very uneasy, nausea, unable to sleep, anxiety & headache. 3 days back I took a multivitamin with 50 mg Magnesium Oxide & I felt better. next day I continued with the multivitamin & I was OK, day before I didn’t take the multivitamin & I had severe problem so I took one. But then body started demanding more, yesterday I had to take twice. Today I bought Magnesium Hydroxide 200 mg and took it twice. I am feeling much better, symptoms have gone down. I am already taking Vitamin D 10000 iu. My confusion is there are different types of Magnesium supplements, which one should I take & how much? Thanks.
I don’t blame you for being confused. The “magnesium in aspartate, citrate, lactate, and chloride forms is absorbed more completely and is more bioavailable than magnesium oxide and magnesium sulfate” and also add the hydroxide to that.
A general rule is to think anything ending in “ate” like citrate is good. Your body can absorb these better and therefore get “better use out of them”.
I would still take the multi each day!! As for the extra magnesium try 500mg more. (Don’t even count what is in the multi.) I try and split mine up during the day with my meals. So for example if you found a “citrate” with 200mg in each pill then either take one with each meal (total 600mg per day) OR at least two meals for a total of 400mg. You will have to judge by your symptoms, how much you need.(Down the road you may need less.) The worse thing that can happen is if you get too much, you will probably get loose bowels and then you need to cut back on the amount you take. Sometimes people take magnesium before bed because it helps them sleep.
Somehow I feel am I falling short in magnesium. My backache has gone but my nausea & slight depression with anxiety keeps coming back though it is less than earlier. After decades of depression & anxiety I do feel a bit hopeful of new therapy. I read a lot positive about this therapy & I am eager to get well. Interestingly, since I started taking Vitamin D3 & now Magnesium, Antidepressant seems to have no effect on me but I am scared to drop them, I take Sertraline 100mg. & also Clonazepam 0.5mg. I am caught between 2 therapies & want to hang in there so I am chattering a bit. Other than nausea I am fine. Unfortunately my Doctor is least helpful with my new therapy. How long will it take for my Vitamin D3 level to come above 50 ng/ml now that I have started taking 10000 iu and what do you mean by I will need less of Magnesium down the road? When will that happen? By the way I am 50 years old male & short in height 5 feet 3 inches, very optimistic person and depression has taught me to have lots of patience. Please give your valuable suggestions. Hope I am not troubling you. Thanks a lot.
At this point I do want you to know I am not a doctor or scientist. When you originally said “I have stopped taking antipsychotic – Risperidone 0.5 mg, given to me for depression”, I was a little anxious. Since you had already stopped it, I did not comment on this. What you will have to understand is I cannot comment on the other drugs (stopping) them because I am not comfortable doing so. I do understand that you are probably not getting much help from your doctor. If someone tells me they are taking an antidepressant I try and warn them of the following if it is a “Reuptake Inhibitor (SSRI)”. If the Vitamin D corrects the depression problem, then I do not know if it is possible to then end up with “serotonin syndrome”. If you do not know this is “high levels of serotonin in the body”. Symptoms include “agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, and fainting”. As you can see agitation and nausea are on the list. So do they belong to the lack of magnesium or serotonin syndrome?
Sometimes I have suggested that people stop the Vitamin D and take several days of magnesium and then try again. I am NOTsuggesting that you do this. You could go at this slower and take the 5000iu for several weeks to a month (I am guessing on the time frame) and then increase it later. Maybe it would lesson some of the symptoms.
Weight can factor in with how much Vitamin D a person needs also. So although 10,000iu is not really a big amount, it can be for some people.
Your levels should increase within two months. Please do not equate the level with feeling well that could be two different things and we will have to wait and see. For example if you took 10,000 for two months, retested and now had a level of 70ng/ml but you still felt slightly depressed, I might suggest trying a little more Vitamin D to see if it helps or not.
One person said they absolutely needed the supplemental Vitamin K to make the D work for their depression. So take the co-factors listed at the link dated May 5th seriously, in your diet or in supplements.
What I meant about the magnesium is this. For years and years you have been “D” deficient. Now you have given yourself a reasonable amount and now your body can do all sorts of good things with it. BUT it does need those co-factors so “my thoughts” are it may cause a “temporary shortage” or a “short term” increased need. After things “level” out maybe you will not need to take as much and still be OK. Only time will tell and this, “I think”, goes for other vitamins and minerals.
If “chattering” helps, it is OK by me!
I will keep in mind about Serotonin Syndrome. Your empathy + knowledge is more important to me it doesn’t matter whether you are a Doctor or not. And Doctors are human too & they have their own protocols. Over a period, patient tends to know more about his body than Doctor especially if he is observant. I will know whether a particular antidepressant suits me or not after 1 or 2 days but Doctor will wait till it fails. I stopped Respiridone because of terrible side effects and after a period of Vitamin D3 I felt I don’t need it. Maybe I am right, it is long time since I stopped & I am OK. Side effects of Respiridone made me put on 10 Kgs of weight & my reflexes became sluggish. I was uncomfortable balancing my two-wheeler especially on tough roads & heavy traffic. I am a fitness lover & was unable to enjoy work outs. Could not be regular. Now my reflexes have returned to normal.
Coming to Serotonin Syndrome, I don’t think I have it as of now. I agree with your suggestion of reducing my dosage to 5000 iu & then increasing after few weeks, this body is unable to handle 10000 iu I think. Initially it could not handle even 5000 iu I had reduced to 2000 iu when it fell short I increased to 3k iu then 4k & 5k. My panic attacks have gone. Today was a better day, no severe nausea. I started taking Vitamin K 40 mcg. My body reacted very positively to Vitamin D3 after the first dose, I felt great after many years as if free of depression. Maybe once my D level comes up I will feel better. I am going to change my Doctor. I will take his guidance for tapering Sertraline. Will also inform him about Vitamin D. Please give your valuable suggestions. Thanks.
I tapered off Sertraline. As of now, for now last 26 days I am not on any Antidepressants or Anti-psychotics. I did experienced lot of withdrawal symptoms but I am OK now. I am do not rule out periodic withdrawal symptoms but believe it will become lesser in intensity. I got the reports of Vit D lev tests, it is 42.15 ng/ml. This is after 2 months of Vitamin D3 10000 iu. I tested Magnesium levels too, they are OK. 1.85 mg.dl. At the moment, I do am facing withdrawal symptoms but they are expected otherwise no panic attacks absolutely. When my withdrawal symptoms increased in previous 2 days I took 2000 iu of D3 extra, don’t that was the cause but I woke up next day, improved. What is your suggestion for me? Which dosage should I continue & what Vitamin D level should I achieve & maintain? What maintenance dosage? It is truly rebirth for me at the age of 50. When people go through midlife crisis I feel rejuvenated. Thanks.
I am so glad you are doing better and feeling better!!!
I was really surprised that your level was not “higher” than what it ended up being on 10,000iu a day for two months. So to answer one of your questions, do NOT take less than 10,000iu a day. Now considering the extra 2000iu the other day, helped with your symptoms, I think you should try an experiment and take more. I will leave how much up to you. You could take 15,000iu a day and see what happens or take 12,000iu a day and see what happens. Maybe either one will get rid of all of your symptoms once and for all. Maybe your “withdraw” symptoms are not withdraw symptoms and you just need more D. (My “guess” would be that 12 will get you to a level of 60 and 15 will probably get you to 80.) More importantly than the level is, does it make you feel better?
Also note that, for example, in times of severe emotional stress or you hurt yourself or you have surgery, you may need more Vitamin D than what you normally take.
Also do not stop taking the magnesium. Blood tests for minerals only measure the 1-2 percent that is found in your blood stream. It does not measure what is in your cells or your bodily stores. So you can “pass” the test and still be deficient.
Let me know what you think!
I have started taking 12000 iu of Vitamin D3. I was feeling alright then I took Alcohol, a good amount, on Sunday, since then I am feeling severe Nausea & anxiety. Still not recovered. What is your suggestion? I shouldn’t have taken alcohol. Will reaching higher levels of Vitamin D help me in stabilizing? Is higher dosage of Vitamin D3 cause some side-effects such as nausea? Could it be because of combined effect higher dosage of Vitamin D3 + high alcohol? What should I do?
Hi. I don’t drink much, once or twice in a month. For last 1 year, whenever I have a drink I suffer anxiety & depression after some time. This was not happening prior to that. What cold be the cause? Could it happen if Vitamin D level in the body becomes too low? Now, from morning, I have started taking Ayurvedic medicine for Liver which has reduced my nausea. Though I also have allergic sneezing & cold, it comes during monsoon. Thanks.
If you think the 12,000 iu is making things worse, than go back to 10,000 iu.
Sometimes if people take too much Vitamin D, even very small amounts, they can get hypercalcemia. The symptoms of hypercalcemia include: feeling sick or being sick, poor appetite or loss of appetite, feeling very thirsty, passing urine often, constipation or diarrhea, abdominal pain, muscle weakness or pain, feeling confused, feeling tired and bone pain. I really do “not” think you have this but a simple way to check is a blood test for calcium levels.
Here is my guess. Now that you are taking Vitamin D, Vitamin D by itself uses a lot of magnesium. A quick check of the internet says that alcohol makes magnesium levels lower. Your symptoms “still point to not enough magnesium”. How much are you taking at this point?
What kind of K are you taking, K1 or K2?
You asked “Does withdrawal from antidepressant makes brain use up more Vitamin D”? I don’t know. Your level “has risen” and that is a good thing. There are probably three reasons it is not higher, One if you are overweight, two maybe your genetic makeup just needs more or three the Vitamin D is still trying to “repair things” and is therefore still using up a lot. (The allergies may actually being using up the Vitamin D.)
Nausea and anxiety usually indicates low magnesium. Depression can be low calcium or potassium.
I too think it is not hypercalcemia. I am taking Magnesium Glycinate 400 mg & Vitamin K2 MK7 40 mcg. These could be Withdrawal symptoms also. It is 1 month since I stopped Sertraline & Sertraline remains in body for 3/4 weeks & withdrawal symptoms may last upto 3 months. Though I will get my Potassium, Calcium & Magnesium checked to be on safe side.
Again when it comes to any mineral a blood test is not the best. Even if it comes up “in the range”, it can be well worth trying a supplement anyway.
Is the 400mg of magnesium all in one pill or capsule? If it is then you could try 800mg but if it is too much then you will get loose bowels. If it is really 200mg in a pill or capsule and you take two then maybe try 3.
You could try doubling the Mk7 to 80mcg a day and see if that changes anything.
Your right it could still be withdrawal symptoms.
I am taking pill of Magnesium Glycinate 400 mg, seeing some gradual improvement over last 2 days. I wanted to know what harm Hypercalcemia can do? If I do reduce the dosage of Vitamin D3 to 10000 iu how will that affect my recovery? Will it take longer? If yes, how long to reach 70 level? If I continue with 12000 iu will my body settle down after few days? Will my body adjust with 12000 iu? I would love to continue with 12000 iu though if it helps early recovery. My nausea, depression and anxiey have gone down but are still there & that is a worry but I can hold on. Please suggest.
Hi, I took Vitamin K2 80 mcg today but degree of improvement is same like yesterday. I have less of Hypercalcemia symptoms. My symptoms are anxiety, depression but not prolonged, goes away after a while & nausea but my appetite is intact. There is frequent urination today but that could also be because of anxiety, no unusual thirst, no confusion though only little worry because of anxiety, no feeling tired or muscle weakness, I know symptoms differ from person to person.
It is my understanding that if you were to have hypercalcemia, you would get most of those symptoms. I really do not think you have this. If you did then you would have to stop the Vitamin D and stay out of the sunshine until your calcium levels returned to “normal”. Then you and a doctor would have to decide if you just took too much Vitamin D and adjust the amount taken or decide if you cannot take it at all because any amount gives you hypercalcemia. Also it only hurts you if you continue to have it for a long time not a short time.
Does the anxiety and depression come within a few hours after ingesting the Vitamin D or does it just come and go at anytime?
You said “I am taking pill of Magnesium Glycinate 400 mg, seeing some gradual improvement over last 2 days”. Does this mean you were not taking it at all or that you “increased the amount taken”?
I think sometimes some people just have to take it a little slower for their recovery. It is great that you can take the 10,000iu so if you have “less symptoms” on that amount, then just take that amount for now. I still think this is caused by “low magnesium”.
The other thing you may want to consider is probiotics and see if that helps the stomach issues.
My stomach is not good for quite some time now. That is expected though if you are stopping antidepressants. I have pain in the stomach too but not constant. Sometimes it occurs. I agree I was fine with 10000 iu & I was taking 200 mg of Magnesium and it was fine now as I increased to 12000 iu I increased Magnesiu to 400 mg. I will of course feel sick due to nausea & anxiety which are the main symptoms now. Depression is not their so much. No tiredness or muscular pain as such though sometimes there is pain in the lower back which is not new though. Inspite of nausea my appetite is intact but bowel movement is not good. I have to go several times. Urination is fine. Now only thing possible, as you said, is Magnesium going down. I am testing Calcium & Magnesium tomorrow though you said they are not good indicators. Just to see. I think I will revert back to 10000 iu. It is fine if it takes longer to raise D level.
I think it is third, Vitamin D3 is still repairing so D level not increasing fast enough. I gained weight after I started taking Antipsychotics & Antidepressants especially antipsychotics. I think my body must be in a mess now. Will take some time to recover. I used to go cycling, around 8 km in the morning stopped after monsoon started. Will continue once we get dry spell.
My Magnesium 2 mg/dl & Calcium 9.34 mg/dl values both are within range as per test. Now I have Nausea, Anxiety & Stomach problem, most probably these are withdrawal symptoms. They do not increase or decrease with intake of supplements, they follow their own path. They surely have gone down since they initially started last week but still are good enough to be troublesome. Last night Nausea was bad. I think I should have waited for D levels to rise before stopping my psychiatric medicines. Anyway now I will wait for this to pass. Does Coenzyme Q10 good for me?
You said “since they initially started last week” the “Nausea, Anxiety & Stomach problem”. When exactly did you stop biking because of the monsoons? Was it is the last two weeks or more?
Here is a very good article and they talk about CoQ10 at http://www.optimallivingdynamics.com/blog/7-important-nutrients-depleted-by-psychiatric-drugs-antidepressants-antipsychotics-stimulants-benzodiazepines-induced-guide-vitamins-medications.
I stopped biking for more than 4 weeks back. Unfortunately. I was doing well. I will restart as soon as possible. The good thing is symptoms are going down & I have not reduced Vitamin D3 to 10000 iu still am taking 12000 iu. Thanks for the article, I will go through it.
Sorry sometimes I have to keep asking questions because of information someone like you gives. Sometimes it is not until there is a back and forth do I then “gleen” (get) more important information.
Even though you “biked” in the morning, it was still adding some Vitamin D to your level of 42ng/ml. The best time for Vitamin D production from sunshine is 10 AM to 2 PM BUT this does not mean you do not make Vitamin D at any other times.
What I think happened is when you had to stop biking, your levels probably went lower,hence why you have some symptoms again or recently. The “biking sunshine” was giving you just enough more to make things better and when that stopped you regressed somewhat.
So if you can take the 12,000iu and you are sure it is not causing the issues and may even be making them better, than you may want to consider taking 15,000iu a day and see what happens.
Before you ask, 15,000iu will not hurt you!
Sorry sometimes I have to keep asking questions because of information someone like you gives. Sometimes it is not until there is a back and forth do I then “gleen” (get) more important i…
Posted by IAW | 2 hours, 11 minutes ago
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