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The sum of many small changes: Vitamin D influences gene expression

Posted on: May 21, 2013   by  John Cannell, MD


When the human genome project mapped its first chromosome in 1999, scientists predicted the human genome would contain over 100,000 active genes. The scientists were shocked to discover that only around 20,000 were eventually identified as active. Non-coding areas make up much of the genome, and they are ultra-conserved — meaning they don’t evolve and are much the same now as they were a million years ago. And, they are much the same in humans as they are in rats. In fact, 95% of your genes are identical to those of a rat.

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2 Responses to The sum of many small changes: Vitamin D influences gene expression

  1. Rebecca Oshiro

    I like the point that “vitamin D3 is not an intervention or drug, but….. is as important as other markers of health (i.e. low serum cholesterol).” A chronically low vitamin D level is just as dangerous as walking around with an elevated cholesterol or blood pressure reading, and I am glad to see this acknowledged by researchers.

  2. Magic

    I took Mevacor and then Lipitor from 1987-2003 when they started advertising …with caveats.

    I stopped in 2003 and still have a half bottle left. I go along with the medical people who say only a fraction of the users need statin drugs. My HDL’s were 44+…at last reading…The highest I have ever had with meds. I believe in exercise, eating well and a collection of vitamins to go along with as many D3s as I need to feel “perfect.” I take no prescription meds and haven’t for years.

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