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Study: Vitamin D levels predict pregnancy following IVF

Posted on: July 2, 2013   by  Vitamin D Council


Women undergoing in vitro fertilization may want to increase their vitamin D levels to up their chances of getting pregnant, according to new research published in the Canadian Medical Association Journal.

The study published last week reports that women with sufficient vitamin D levels were significantly more likely to get pregnant following in vitro fertilization (IVF) compared to those with insufficient or deficient levels. IVF is a major treatment for fertility issues in which a woman’s egg is fertilized by sperm outside the body.

Researchers at Mount Sinai Hospital in Toronto examined 173 Canadian women undergoing IVF treatment between the ages of 18 and 41. Vitamin D status was assessed in all participants within 1 week of removal of eggs from the woman’s ovaries.

The researchers found that 55% of women had sufficient (>30 ng/ml) vitamin D levels while 45% had insufficient levels (<30 ng/ml). They also report that women with sufficient levels had a significantly higher pregnancy rate (53%) than women with insufficient D levels (35%). Additionally, the implantation – occurs when the embryo attaches to the uterus wall – rate was higher in the sufficient group (35%) than in the insufficient group (26%), although this finding wasn’t significant.

The authors conclude that more research is needed, as the mechanism by which vitamin D affects fertility is still unclear. For the time being, the authors believe vitamin D supplementation may be a cost effective way for improving fertility. They add that examining vitamin D levels as part of routine fertility assessment may be beneficial.


Garbedian K, et al. Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization. Canadian Medical Association Journal Open, 2013

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