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Study finds U-shaped relationship between pre-hospital vitamin D status and mortality

Posted on: June 11, 2014   by  Will Hunter


A new cohort study found that both low and high vitamin D levels before hospital admission are associated with increased risk for all-cause mortality.

A number of studies have examined the effects of low vitamin D status on health outcomes and mortality. For example, a review of randomized controlled trials found a 3-7% reduction in all-cause mortality in non-hospitalized adults who were given vitamin D, compared to adults who were given a placebo.

Researchers haven’t extensively studied the effect of very high vitamin D status on health outcomes and mortality.

This lack of research is reflected by a lack of consensus among the scientific community regarding the acceptable lower and upper limits of vitamin D levels. However, a wide therapeutic window exists for vitamin D and toxicity is only associated with levels of 150 ng/ml or more.

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Amrein, K. et al. Evidence for a U-shaped relationship between prehospital vitamin D status and mortality: a cohort study. The Journal of Clinical Endocrinology and Metabolism, 2014.

3 Responses to Study finds U-shaped relationship between pre-hospital vitamin D status and mortality

  1. Ian

    I think it has come to the point in mortality studies with vitamin D that we should be looking at two measures. Serum 25OH-vitaminD as well as activated vitamin D; 1,25(OH)2-vitaminD. In this study’s, “higher mortality in the group >60ng/ml”, it would be helpful to know the activated vitamin D levels. It could be that serum levels of 25OH-D are high at the expense of low levels of 1,25(OH)2-D. Possibly as a result of poor kidney function in these people.

  2. hlahore@gmail.com

    We have itemized 9 possible reasons for excessive vitamin D being a problem when going into a hospital. #1 is the fact that dose levels of drugs and chemotherapy are designed for patients with low vitamin D levels. Having more vitamin D often results in making the drug/chemo more powerful – to the point of being deadly. Having a good level of vitamin D is NOT a problem when going to a hospital if the doctors will adjust the dose accordingly. Example: need about 1/3 the amount of chemo drugs if you have a high level of vitamin D. This is great since having 1/3 as much chemo will will the cancer just a well without your losing hair, etc.
    Details at http://vitamindwiki.com/tiki-index.php?page_id=5297

  3. Will Hunter


    I agree with you. There might be something else going on that predisposes people to have higher vitamin D levels and increased risk of mortality.

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