Statins are anti-inflammatory, no question about it. But how do they work in inflammation? In human cardiovascular diseases, endothelial dysfunction (ED) is an inflammatory pathological state of the inner lining of blood vessels (endothelium) that leads to cardiovascular disease. Normal functions of endothelial cells include facilitation of coagulation, platelet adhesion, immune function, and control of volume and electrolyte content in and out of the blood vessels. Both statins and vitamin D reduce this endothelial inflammation.