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Vitamin D Research

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Lymphoid Cancer

c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D. Leuk Res. 2009 Oct;33(10):1372–8.
Dietary vitamin D and risk of non-Hodgkin lymphoma: the multiethnic cohort. Br J Nutr. 2009 Sep 28:1–4.
Chemotherapy-Induced Hypocalcemia. Endocr Pract. 2009 Sep 28:1–17.
Calcium, vitamin D and cancer. Anticancer Res. 2009 Sep;29(9):3687–98. Review.
Current impediments to acceptance of the ultraviolet-B-vitamin D-cancer hypothesis. Anticancer Res. 2009 Sep;29(9):3597–604. Review.
Synthesis and biological activities of 14-epi-MART-10 and 14-epi-MART-11: implications for cancer and osteoporosis treatment. Anticancer Res. 2009 Sep;29(9):3563–9.
Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiological studies. Eur J Cancer Prev. 2009 Aug 26.
Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals. Mol Carcinog. 2009 Aug;48(8):758–72.
Multiple myeloma and cancer: is there a D-lightful connection? Am J Hematol. 2009 Jul;84(7):393–4.
Acute leukemia among the adult population of United Arab Emirates: an epidemiological study. Leuk Lymphoma. 2009 Jul;50(7):1138–47.
Review and meta-analysis on Vitamin D Receptor polymorphisms and cancer risk. Carcinogenesis. 2009 Jul;30(7):1170–80.
Impact of vitamin D deficiency on the clinical presentation and prognosis of patients with newly diagnosed multiple myeloma. Am J Hematol. 2009 Jul;84(7):397–400.
Synergistic induction of gene expression during the differentiation into mature macrophage in human myeloblastic leukemia cells treated with TPA and KH1060. Leuk Res. 2009 Jun;33(6):803–9.
Treatment of K562 cells with 1,25-dihydroxyvitamin D(3) induces distinct alterations in the expression of apoptosis-related genes BCL2, BAX, BCL(XL), and p21. Ann Hematol. 2009 May 28.
Differentiation therapy of leukemia: 3 decades of development. Blood. 2009 Apr 16;113(16):3655–65. Review.
Oncogenic nucleoporin CAN/Nup214 interacts with vitamin D receptor and modulates its function. J Cell Biochem. 2009 Apr 15;106(6):1090–101.
Treatment of osteoporosis/osteopenia in pediatric leukemia and lymphoma. Ann Pharmacother. 2009 Apr;43(4):714–20.
Decreased bone turnover despite persistent secondary hyperparathyroidism during prolonged treatment with imatinib. J Clin Endocrinol Metab. 2009 Apr;94(4):1131–6.
Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells. J Steroid Biochem Mol Biol. 2009 Apr;114(3–5):144–51.
Impact of vitamin D deficiency on the clinical presentation and prognosis of patients with newly diagnosed multiple myeloma. Am J Hematol. 2009 Mar 23.
MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3. Cell Cycle. 2009 Mar 1;8(5):736–41.
Association of drug metabolism gene polymorphisms with toxicities, graft-versus-host disease and survival after HLA-identical sibling hematopoietic stem cell transplantation for patients with leukemia. Leukemia. 2009 Mar;23(3):545–56.
Effects of platelet-derived growth factor, vitamin D and parathyroid hormone on osteoblasts derived from cancer patients on chronic bisphosphonate therapy. Int J Mol Med. 2009 Mar;23(3):407–13.
A prospective investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers. Int J Cancer. 2009 Feb 15;124(4):979–86.
Novel Gemini vitamin D(3) analogs have potent antitumor activity. J Steroid Biochem Mol Biol. 2008 Nov;112(1–3):151–6.
A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression. J Steroid Biochem Mol Biol. 2008 Nov;112(1–3):47–54.
Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design. Contemp Clin Trials. 2008 Sep;29(5):711–9.
hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cells. Mol Cancer Ther. 2008 Sep;7(9):2798–806.
Prospective study of combined treatment with interferon-alpha and active vitamin D3 for Japanese patients with metastatic renal cell carcinoma. Int J Urol. 2008 Sep;15(9):794–9.
G0S2 is an all-trans-retinoic acid target gene. Int J Oncol. 2008 Aug;33(2):397–404.
Long-term clinical remission of a patient with chronic lymphocytic leukemia using alternative treatment option: cottonseed oil (gossypol). Phytomedicine. 2008 Aug;15(8):563–5.
1alpha,25-Dihydroxyvitamin D(3)-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells. J Steroid Biochem Mol Biol. 2008 Jun;110(3–5):269–77.
Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1,25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling. Cell Cycle. 2008 Apr 1;7(7):917–24.
Imatinib mesylate (IM)-induced growth inhibition is associated with production of spliced osteocalcin-mRNA in cell lines. Leuk Res. 2008 Mar;32(3):437–43.
Vitamin D status and bone biomarkers in childhood cancer. Pediatr Blood Cancer. 2008 Feb;50(2 Suppl):479–82; discussion 486. Review.
(2S,2'R)-analogue of LG190178 is a major active isomer. Bioorg Med Chem Lett. 2008 Jan 1;18(1):120–3.
Vitamin D insufficiency underlies unexpected hypocalcemia following high dose glucocorticoid therapy. Bone. 2008 Jan;42(1):226–8.
Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors. Exp Hematol. 2008 Jan;36(1):28–36.
Effect of 1,25(OH)2-vitamin D on bone mass in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2008 Jan;30(1):15–9.
Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia. Oncology. 2008;75(3–4):203–14.
Enhancing effects of ceramide derivatives on 1,25-dihydroxyvitamin D(3)-induced differentiation of human HL-60 leukemia cells. Life Sci. 2007 Dec 14;81(25–26):1638–44.
Resistance to 1,25D-induced differentiation in human acute myeloid leukemia HL60-40AF cells is associated with reduced transcriptional activity and nuclear localization of the vitamin D receptor. J Cell Physiol. 2007 Dec;213(3):816–25.
PTHrP-independent hypercalcemia with increased proinflammatory cytokines and bone resorption in two children with CD19-negative precursor B acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007 Dec;49(7):990–3.
Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia? Haematologica. 2007 Nov;92(11):1553–6.
Synergistic interactions between 12-0-tetradecanoylphorbol-13-acetate (TPA) and imatinib in patients with chronic myeloid leukemia in blastic phase that is resistant to standard-dose imatinib. Leuk Res. 2007 Oct;31(10):1441–4.
The MN1-TEL myeloid leukemia-associated fusion protein has a dominant-negative effect on RAR-RXR-mediated transcription. Oncogene. 2007 Aug 23;26(39):5733–40.
Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamin D(3) and is required for optimal cell differentiation. Exp Cell Res. 2007 Aug 15;313(14):3034–45.
SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am J Pathol. 2007 Aug;171(2):654–66.
Calcitriol derivatives with two different side-chains at C-20. Part 4: further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells. Bioorg Med Chem. 2007 Jul 1;15(13):4444–55.
Chaperone-rich cell lysate embedded with BCR-ABL peptide demonstrates enhanced anti-tumor activity against a murine BCR-ABL positive leukemia. FASEB J. 2007 Jul;21(9):2173–84.
Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation. Eur J Cancer. 2007 Jul;43(11):1701–12.
An ecologic study of cancer mortality rates in Spain with respect to indices of solar UVB irradiance and smoking. Int J Cancer. 2007 Mar 1;120(5):1123–8.
Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role? Lung Cancer. 2007 Mar;55(3):263–70.
Favourable and unfavourable effects of exposure to sunlight. Ned Tijdschr Geneeskd. 2007 Jan 13;151(2):118–22. Review.
Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993–2002. BMC Cancer. 2006 Nov 10;6:264.
Ultraviolet radiation, dietary vitamin D, and risk of non-Hodgkin lymphoma (United States). Cancer Causes Control. 2006 Oct;17(8):1045–52.
Does sunlight prevent cancer? A systematic review. Eur J Cancer. 2006 Sep;42(14):2222–32. Review.
Epidemiology of disease risks in relation to vitamin D insufficiency. Prog Biophys Mol Biol. 2006 Sep;92(1):65–79. Review.
Does sunlight have a beneficial influence on certain cancers? Prog Biophys Mol Biol. 2006 Sep;92(1):132–9. Review.
The likely role of vitamin D from solar ultraviolet-B irradiance in increasing cancer survival. Anticancer Res. 2006 Jul–Aug;26(4A):2605–14.
The rationale for deltanoids in therapy for myeloid leukemia: role of KSR-MAPK-C/EBP pathway. J Steroid Biochem Mol Biol. 2005 Oct;97(1–2):47–55.
Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D. Br J Cancer. 2005 Sep 5;93(5):571–4.
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB. 2005 Jul;19(9):1067–77.
Sun exposure may protect against non-Hodgkin lymphoma: a case-control study. Int J Cancer. 2004 Dec 10;112(5):865–71.
Ecologic studies of solar UVB radiation and cancer mortality rates. Recent Results Cancer Res. 2003;164:371–7. Review.
An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer. 2002 Mar 15;94(6):1867–75.
Forced expression of the cyclin-dependent kinase inhibitor p16(INK4A) in leukemic U-937 cells reveals dissociation between cell cycle and differentiation. Exp Hematol. 2001 Dec;29(12):1382–91.
Vitamin D and genomic stability. Mutat Res. 2001 Apr 18;475(1–2):69–87. Review.
A hypothesis concerning deficiency of sunlight, cold temperature, and influenza epidemics associated with the onset of acute lymphoblastic leukemia in northern Finland. Ann Hematol. 1999 Sep;78(9):408–14.
20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines. Anticancer Res. 1999 May–Jun;19(3A):1689–97.
19-nor-26,27-bishomo-vitamin D3 analogs: a unique class of potent inhibitors of proliferation of prostate, breast, and hematopoietic cancer cells. Cancer Res. 1998 Aug 1;58(15):3370–5.
Residential and occupational exposure to sunlight and mortality from non-Hodgkin's lymphoma: composite (threefold) case-control study. BMJ. 1997 May 17;314(7092):1451–5.
Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells. Cancer Res. 1996 Aug 1;56(15):3570–6.
Potent vitamin D3 analogs: their abilities to enhance transactivation and to bind to the vitamin D3 response element. Leuk Res. 1995 Mar;19(3):147–58.
Vitamin D3 analogs: effect on leukemic clonal growth and differentiation, and on serum calcium levels. Leuk Res. 1995 Jan;19(1):65–72.
Murine retrovirus induces defects in the function of dendritic cells at early stages of infection. Cell Immunol. 1994 Oct 1;158(1):167–81.
1,25(OH)2-16ene-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia. Leuk Res. 1994 Jun;18(6):453–63.
Vitamin-regulated retinoblastoma tumor suppressor gene expression in leukemic cells. Adv Exp Med Biol. 1994;354:1–18.
Beneficial effects of sun exposure on cancer mortality. Prev Med. 1993 Jan;22(1):132–40. Review.
Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone mobilization. Blood. 1989 Jul;74(1):82–93.
Sensitivity of Burkitt lymphoma Daudi cells to inactive influenza virus. J Cancer Res Clin Oncol. 1989;115(1):61–6.
1,25-Dihydroxyvitamin D3: in vivo and in vitro effects on human preleukemic and leukemic cells. Cancer Treat Rep. 1985 Dec;69(12):1399–407.
Mechanism of the differentiating action of 25-hydroxyvitamin D3 endoperoxides in human myeloid leukemia cells (HL-60). J Med Chem. 1985 Sep;28(9):1153–8.
Syntheses and differentiating action of vitamin D endoperoxides. Singlet oxygen adducts of vitamin D derivatives in human myeloid leukemia cells (HL-60). J Med Chem. 1985 Sep;28(9):1148–53.
Vitamin D: myeloid differentiation and proliferation. Haematol Blood Transfus. 1985;29:409–17.
Biological activity of 24,24-difluoro-1 alpha, 25-dihydroxyvitamin D3 and 1 alpha, 25-dihydroxyvitamin D3-26,23-lactone in inducing differentiation of human myeloid leukemia cells. Arch Biochem Biophys. 1983 Jan;220(1):90–4.

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