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Vitamin D Research

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Liver Cancer

Fish oil enhances the antiproliferative effect of 1alpha,25-dihydroxyvitamin D3 on liver cancer cells. Anticancer Res. 2009 Sep;29(9):3591–6.
Inverse association between serum concentrations of actin-free vitamin D-binding protein and the histopathological extent of fibrogenic liver disease or hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):990–5.
Prognosis factors of cholangiocarcinoma: contribution of recent molecular biology tools. Bull Cancer. 2009 Apr 1;96(4):405–415.
Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345–60.
Inhibition of hepatocellular cancer by EB1089: in vitro and in vive study. Anticancer Res. 2008 Nov–Dec;28(6A):3757–61.
Multiple extragenital adenomatoid tumors in the mesocolon and omentum. APMIS. 2008 Nov;116(11):1016–9.
Adenomatoid tumour of the liver. J Clin Pathol. 2008 Jun;61(6):777–80.
Primary malignant mesothelioma developed in liver. Hepatogastroenterology. 2008 May–Jun;55(84):1081–4.
Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation. Eur J Cancer. 2007 Jul;43(11):1701–12.
Chaperone-rich cell lysate embedded with BCR-ABL peptide demonstrates enhanced anti-tumor activity against a murine BCR-ABL positive leukemia. FASEB J. 2007 Jul;21(9):2173–84.
Calcitriol inhibits the growth of MHCC97 heptocellular cell lines by down-modulating c-met and ERK expressions. Liver Int. 2007 Jun;27(5):700–7.
Vitamin d and its role in cancer and immunity: a prescription for sunlight. Nutr Clin Pract. 2007 Jun;22(3):305–22. Review.
Does solar ultraviolet irradiation affect cancer mortality rates in China? Asian Pac J Cancer Prev. 2007 Apr–Jun;8(2):236–42.
Treatment of primary sclerosing cholangitis. Curr Treat Options Gastroenterol. 2007 Mar;10(2):111–9.
Selective vitamin D receptor modulators and their effects on colorectal tumor growth. J Steroid Biochem Mol Biol. 2007 Mar;103(3–5):757–62.
Nuclear hormone receptors in human skin. Horm Metab Res. 2007 Feb;39(2):96–105. Review.
Inhibition of LXRalpha signaling by vitamin D receptor: possible role of VDR in bile acid synthesis. Biochem Biophys Res Commun. 2006 Dec 8;351(1):176–84.
Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. Curr Cancer Drug Targets. 2006 Dec;6(8):711–27. Review.
Positional expression profiling indicates candidate genes in deletion hotspots of hepatocellular carcinoma. Mod Pathol. 2006 Dec;19(12):1546–54.
Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993–2002. BMC Cancer. 2006 Nov 10;6:264.
Vitamin D: its role in cancer prevention and treatment. Prog Biophys Mol Biol. 2006 Sep;92(1):49–59. Review.
Xenografts of human hepatocellular carcinoma: a useful model for testing drugs. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4306–14.
Chemoprevention in gastrointestinal cancers: current status. Basic Clin Pharmacol Toxicol. 2006 Mar;98(3):281–7. Review.
Growth inhibition of cancer cells by an active metabolite of a novel vitamin D prodrug. Anticancer Res. 2005 Nov–Dec;25(6B):4333–9.
Hepatocellular carcinoma with mesothelioma-like dissemination. Pathol Int. 2005 Nov;55(11):738–44.
Inhibition of apolipoprotein AI gene expression by 1, 25-dihydroxyvitamin D3. Biochim Biophys Acta. 2005 Oct 15;1737(1):16–26.
Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues. J Steroid Biochem Mol Biol. 2005 Oct;97(1–2):153–64.
Effects of vitamin D analogue EB1089 on proliferation and apoptosis of hepatic carcinoma cells. Zhonghua Yu Fang Yi Xue Za Zhi. 2004 Nov;38(6):415–8.
Genetically modified mice and their use in developing therapeutic strategies for prostate cancer. J Urol. 2004 Jul;172(1):12–9. Review.
1alpha, 25-dihydroxyvitamin D3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital. World J Gastroenterol. 2004 May 1;10(9):1268–75.
Systemic treatment of hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 2004 Mar;16(3):275–81. Review.
Regulatory mechanism of EB1089 for hepatocarcinoma cell proliferation. Wei Sheng Yan Jiu. 2004 Mar;33(2):140–3.
Retroperitoneal mucinous cystadenoma: report of two cases and review of the literature. Pathol Int. 2004 Feb;54(2):132–8.
A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma. Br J Cancer. 2003 Jul 21;89(2):252–7.
Hormonal regulation of the human sterol 27-hydroxylase gene CYP27A1. Biochem J. 2003 Jun 1;372(Pt 2):529–34.
Significant experimental decrease of the hepatocellular carcinoma incidence in C3H/Sy mice after long-term administration of EB1089, a vitamin D analogue. Oncol Res. 2003;13(5):261–8.
Localized malignant mesothelioma of the epithelial type occurring as a primary hepatic neoplasm: a case report with review of the literature. APMIS. 2002 Nov;110(11):789–94.
1alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes and the development of gamma-glutamyltranspeptidase-positive foci in diethylnitrosamine-initiated and streptozotocin-induced diabetes-promoted hepatocarcinogenesis. Cell Biochem Funct. 2002 Sep;20(3):195–204.
Lung cancer associated with hypercalcemia induced by concurrently elevated parathyroid hormone and parathyroid hormone-related protein levels. Metabolism. 2002 Jul;51(7):871–5.
Vitamin D receptor as an intestinal bile acid sensor. Science. 2002 May 17;296(5571):1313–6.
Tumor cell alpha-N-acetylgalactosaminidase activity and its involvement in GcMAF-related macrophage activation. Comp Biochem Physiol A Mol Integr Physiol. 2002 May;132(1):1–8.
Cushing's syndrome caused by paraneoplastic ACTH secretion 11 years after occurence of a medullary thyroid carcinoma. Dtsch Med Wochenschr. 2002 Apr 19;127(16):850–2.
Pharmacokinetic and pharmacodynamic evaluation of intermittent versus continuous alendronate administration in rats. J Pharm Sci. 2002 Feb;91(2):508–16.
A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis. 2001 Nov;22(11):1871–5.
Hypercalcaemia of melanoma: incidence, pathogenesis and therapy with bisphosphonates. Melanoma Res. 2001 Oct;11(5):477–82.
1Alpha,25-dihydroxyvitamin D3 inhibits hepatic chromosomal aberrations, DNA strand breaks and specific DNA adducts during rat hepatocarcinogenesis. Cell Mol Life Sci. 2001 Jul;58(8):1141–9.
1 alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis. J Cell Biochem. 2001 Mar 26;81(2):357–67.
In vitro metabolism of 19-nor-1alpha, 25-(OH)2D2 in cultured cell lines: inducible synthesis of lipid- and water-soluble metabolites. Arch Biochem Biophys. 2001 Mar 15;387(2):297–306.
Evolution of a case of tyrosinemia type I treated with NTBC. An Esp Pediatr. 2001 Mar;54(3):305–9.
Expression of CYP27A, a gene encoding a vitamin D-25 hydroxylase in human liver and kidney. Clin Endocrinol (Oxf). 2001 Jan;54(1):107–15.
1alpha, 25-Dihydroxyvitamin D3 suppresses the effect of streptozotocin-induced diabetes during chemical rat liver carcinogenesis. Cell Biol Int. 2001;25(3):227–37.
Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3). Biochim Biophys Acta. 2000 Oct 18;1502(2):273–82.
The role of vitamin D3 receptor mRNA in the proliferation of hepatocellular carcinoma. Hepatogastroenterology. 2000 Mar–Apr;47(32):468–72.
Bioactive phytochemicals with emphasis on dietary practices. Indian J Med Res. 1998 Nov;108:167–81. Review.
Selenium, calcium channel blockers, and cancer risk—the Yin and Yang of apoptosis? Med Hypotheses. 1998 May;50(5):423–33.
Expression of a vitamin D-regulated gene (VDUP-1) in untreated- and MNU-treated rat mammary tissue. Breast Cancer Res Treat. 1998 Mar;48(1):33–44.
Induction of sialic acid 9-O-acetylation by diverse gene products: implications for the expression cloning of sialic acid O-acetyltransferases. Glycobiology. 1998 Feb;8(2):199–205.
Influence of the vitamin D status on the early hepatic response to carcinogen exposure in rats. J Pharmacol Exp Ther. 1997 Apr;281(1):464–9.
Tissue-specific expression and regulation by 1,25(OH)2D3 of chick protein kinase inhibitor (PKI) mRNA. Endocrine. 1997 Feb;6(1):5–10.
New rodent models for studies of chemopreventive agents. J Cell Biochem Suppl. 1997;28–29:144–7. Review.
Immunosuppression—a tightrope walk between iatrogenic harm and therapy. Schweiz Med Wochenschr. 1996 Sep 21;126(38):1603–9. Review.
Differential modulation of thyroid hormone responsiveness by retinoids in a human cell line. Endocrinology. 1996 Aug;137(8):3187–92.
In vitro metabolism of the vitamin D analog, 22-oxacalcitriol, using cultured osteosarcoma, hepatoma, and keratinocyte cell lines. J Biol Chem. 1996 Apr 12;271(15):8700–8.
Identification of estrogen regulated genes in Fe33 rat hepatoma cells by differential display polymerase chain reaction and their hormonal regulation in rat liver and uterus. J Steroid Biochem Mol Biol. 1995 Dec;55(3–4):363–73.
1 alpha,24(S)-dihydroxyvitamin D2: a biologically active product of 1 alpha-hydroxyvitamin D2 made in the human hepatoma, Hep3B. Biochem J. 1995 Aug 15;310 ( Pt 1):233–41.
Alpha-fetoprotein (AFP) expression in clones of McA-RH 7777 rat hepatoma: correlation with the occurrence of homogeneously staining regions on chromosome 14. Cancer Res. 1995 Aug 15;55(16):3615–22.
The vitamin D Endocrine system: manipulation of structure-function relationships to provide opportunities for development of new cancer chemopreventive and immunosuppressive agents. J Cell Biochem Suppl. 1995;22:218–25. Review.
Effects of 1,25-dihydroxyvitamin D3 on proliferation and differentiation of Caco-2 cells. Endocrinology. 1994 Apr;134(4):1710–7.
Dexamethasone increases the expression of retinoid X receptor genes in rat hepatoma cell lines. Lab Invest. 1994 Apr;70(4):547–52.
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol. 1993 Oct;7(10):1244–55.
Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side-chain positions. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8668–72.
In vivo metabolism of the vitamin D analog, dihydrotachysterol. Evidence for formation of 1 alpha,25- and 1 beta,25-dihydroxy-dihydrotachysterol metabolites and studies of their biological activity. J Biol Chem. 1993 Jan 5;268(1):282–92.
Hormonal regulation of vitamin D-binding protein production by a human hepatoma cell line. Biochem Int. 1992 Nov;28(3):551–7.
Depression of plasma gelsolin level during acute liver injury. Gastroenterology. 1992 May;102(5):1686–92.
The metabolism of dihydrotachysterols: renal side chain and non-renal nuclear hydroxylations in vivo and in vitro. J Steroid Biochem Mol Biol. 1992 Mar;41(3–8):859–70.
Effect of active vitamin D3 on the levels of NADPH-dependent cytosolic 3,5,3'-triiodo-L-thyronine-binding protein. Biochem Biophys Res Commun. 1991 May 31;177(1):388–94.
Evaluation of bone resorption and renal tubular reabsorption of calcium and phosphate in malignant and nonmalignant hypercalcemia. Bone. 1991;12(1):47–56.
An emerging view of vitamin D. Scand J Clin Lab Invest Suppl. 1990;201:127–33. Review.
A case of a gallbladder cancer with marked hypercalcemia and leukocytosis. Jpn J Med. 1989 Nov–Dec;28(6):722–6.
Plasma carriers influence the uptake of cholecalciferol by human hepatoma-derived cells. J Bone Miner Res. 1989 Apr;4(2):243–7.
1,25-Dihydroxyvitamin D3-induced growth restriction of cultured epithelial cells derived from a murine hepatic tumor. Biochem Pharmacol. 1989 Feb 1;38(3):449–53.
25-Hydroxylation of vitamin D3 in the human hepatoma cell lines Hep G2 and Hep 3B. J Lipid Res. 1988 Dec;29(12):1637–42.
Vitamin D-binding protein synthesized by a human hepatocellular carcinoma cell line. Clin Chim Acta. 1987 Aug 31;167(3):273–84.
Characterization of the human plasma binding protein for vitamin D and its metabolites synthesized by the human hepatoma-derived cell line, Hep 3B. J Biol Chem. 1983 Jun 10;258(11):6850–4.
Group-specific component [Gc] levels in chronic liver disease. J Med. 1978;9(2):109–15.

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