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Vitamin D Research

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Colon and Rectal Cancer

Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU. Int J Cancer. 2010 Feb 1;126(3):631–9.
The yin and yang of vitamin D receptor (VDR) signaling in neoplastic progression: operational networks and tissue-specific growth control. Biochem Pharmacol. 2010 Jan 1;79(1):1–9. Review.
Vitamin D: Proteases, protease inhibitors and cancer. Cell Cycle. 2010 Jan 1;9(1):32–7.
SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue. Oncogene. 2009 Dec 10;28(49):4375–85.
Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines. PLoS One. 2009 Nov 17;4(11):e7872.
Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D(3). Oncogene. 2009 Nov 5;28(44):3892–902.
Effects of vitamin d and calcium on proliferation and differentiation in normal colon mucosa: a randomized clinical trial. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2933–41.
Vitamin D receptor expression is associated with colon cancer in ulcerative colitis. Oncol Rep. 2009 Nov;22(5):1021–5.
High vitamin D levels and improved quality of life in a patient with metastatic colorectal cancer: case report. Tenn Med. 2009 Oct;102(10):37–8.
Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2765–72.
Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer. J Nutr. 2009 Sep 16.
Modulation of vitamin D synthesis and catabolism in colorectal mucosa: a new target for cancer prevention. Anticancer Res. 2009 Sep;29(9):3705–12. Review.
Calcium, vitamin D and cancer. Anticancer Res. 2009 Sep;29(9):3687–98. Review.
Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro. Anticancer Res. 2009 Sep;29(9):3659–67.
Current impediments to acceptance of the ultraviolet-B-vitamin D-cancer hypothesis. Anticancer Res. 2009 Sep;29(9):3597–604. Review.
The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res. 2009 Sep;29(9):3511–36. Review.
Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk. Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2540–8.
Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2485–91.
Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. Carcinogenesis. 2009 Aug;30(8):1459–68.
Vitamin D mediates its action in human colon carcinoma cells in a calcium sensing receptor dependent manner: Down-regulates malignant cell behavior, the expression of thymidylate synthase, survivin and promotes cellular sensitivity to 5-FU. Int J Cancer. 2009 Jul 20.
Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther. 2009 Jul 1;30(2):113–25.
Vitamin D for cancer prevention: global perspective. Ann Epidemiol. 2009 Jul;19(7):468–83.
Treatment of K562 cells with 1,25-dihydroxyvitamin D(3) induces distinct alterations in the expression of apoptosis-related genes BCL2, BAX, BCL(XL), and p21. Ann Hematol. 2009 May 28.
MutL-homolog 1 expression and risk of incident, sporadic colorectal adenoma: search for prospective biomarkers of risk for colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1599–609.
Review and meta-analysis on Vitamin D Receptor polymorphisms and cancer risk. Carcinogenesis. 2009 Apr 29.
Vitamin D Gene Pathway Polymorphisms and Risk of Colorectal, Breast, and Prostate Cancer. Annu Rev Nutr. 2009 Apr 21.
Comment on interaction of hormone replacement therapy with calcium and vitamin D supplementation on colorectal cancer risk. Int J Cancer. 2009 Apr 1;124(7):1736; author reply 1737–8.
Effects of vitamin D and calcium supplementation on markers of apoptosis in normal colon mucosa: a randomized, double-blind, placebo-controlled clinical trial. Cancer Prev Res (Phila Pa). 2009 Mar;2(3):213–23.
Vitamin D receptor gene polymorphisms and the risk of colorectal cancer in a Chinese population. Dig Dis Sci. 2009 Mar;54(3):634–9.
Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer. Int J Colorectal Dis. 2009 Feb;24(2):219–24.
Risk of prostate, breast and colorectal cancer after skin cancer diagnosis. Int J Cancer. 2008 Dec 15;123(12):2899–901.
Geographic location and vitamin D synthesis. Mol Aspects Med. 2008 Dec;29(6):453–61.
Dietary calcium, vitamin D, and the risk of colorectal cancer. Am J Clin Nutr. 2008 Dec;88(6):1576–83.
The vitamin D deficiency pandemic and consequences for nonskeletal health: Mechanisms of action. Mol Aspects Med. 2008 Dec;29(6):361–8. Review.
RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. Journal of Cell Biology. 2008 Nov 17. Vol. 183, No. 4, 697–710.
Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Int J Cancer. 2008 Nov 1;123(9):2170–9.
Vitamin D and prevention of colorectal adenoma: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):2958–69.
Novel Gemini vitamin D(3) analogs have potent antitumor activity. J Steroid Biochem Mol Biol. 2008 Nov;112(1–3):151–6.
A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression. J Steroid Biochem Mol Biol. 2008 Nov;112(1–3):47–54.
Superagonistic fluorinated vitamin d(3) analogs stabilize helix 12 of the vitamin d receptor. Chem Biol. 2008 Oct 20;15(10):1029–34.
HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. Cancer Biol Ther. 2008 Oct 7;7(10).
Dietary induction of colonic tumors in a mouse model of sporadic colon cancer. Cancer Res. 2008 Oct 1;68(19):7803–10.
Vanadium and 1, 25 (OH)2 vitamin D3 combination in inhibitions of 1,2, dimethylhydrazine-induced rat colon carcinogenesis. Biochim Biophys Acta. 2008 Oct;1780(10):1106–14.
Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2800–7.
Genetic variation in calcium-sensing receptor and risk for colon cancer. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2755–65.
Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis. 2008 Sep;29(9):1788–93.
Vitamin D and Sunlight: Strategies for Cancer Prevention and Other Health Benefits. Clin J Am Soc Nephrol. 2008 Sep;3(5):1548–54.
Dietary supplement use among elderly, long-term cancer survivors. J Cancer Surviv. 2008 Sep;2(3):138–48.
Serum vitamin D concentration and prostate cancer risk: a nested case-control study. J Natl Cancer Inst. 2008 Jun 4;100(11):796–804.
Prevalence & potential significance of vitamin D deficiency in Asian Indians. Indian J Med Res. 2008 Mar;127(3):229–38. Review.
Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs). Adv Exp Med Biol. 2008;624:203–14. Review.
Colon cancer: prognosis for different latitudes, age groups and seasons in Norway. J Photochem Photobiol B. 2007 Dec 14;89(2–3):148–55.
Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2623–30.
Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study. Br J Cancer. 2007 Aug 6;97(3):446–51.
Vitamin D and the regulation of Wnt/beta-catenin signaling and innate immunity in colorectal cancer. Nutr Rev. 2007 Aug;65(8 Pt 2):S118–20. Review.
A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer. J Natl Cancer Inst. 2007 Jul 18;99(14):1120–9.
Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation. Eur J Cancer. 2007 Jul;43(11):1701–12.
An ecologic study of cancer mortality rates in Spain with respect to indices of solar UVB irradiance and smoking. Int J Cancer. 2007 Mar 1;120(5):1123–8.
A meta-analysis of second cancers after a diagnosis of nonmelanoma skin cancer: Additional evidence that solar ultraviolet-B irradiance reduces the risk of internal cancers. J Steroid Biochem Mol Biol. 2007 Mar;103(3–5):668–74.
Optimal vitamin d status for colorectal cancer prevention a quantitative meta analysis. Am J Prev Med. 2007 Mar;32(3):210–6.
Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role? Lung Cancer. 2007 Mar;55(3):263–70.
Favourable and unfavourable effects of exposure to sunlight. Ned Tijdschr Geneeskd. 2007 Jan 13;151(2):118–22. Review In Dutch.
1,25-Dihydroxyvitamin D(3) regulates genes responsible for detoxification in intestine. Toxicol Appl Pharmacol. 2007 Jan 1;218(1):37–44.
Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993–2002. BMC Cancer. 2006 Nov 10;6:264.
The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas. Int J Cancer. 2006 Nov 1;119(9):2098–104.
Cancer survival is dependent on season of diagnosis and sunlight exposure. Int J Cancer. 2006 Oct 1;119(7):1530–6.
Does sunlight prevent cancer? A systematic review. Eur J Cancer. 2006 Sep;42(14):2222–32. Review.
Epidemiology of disease risks in relation to vitamin D insufficiency. Prog Biophys Mol Biol. 2006 Sep;92(1):65–79. Review.
Does sunlight have a beneficial influence on certain cancers? Prog Biophys Mol Biol. 2006 Sep;92(1):132–9. Review.
Vitamin D: its role in cancer prevention and treatment. Prog Biophys Mol Biol. 2006 Sep;92(1):49–59. Review.
Vitamin D deficiency: A global perspective. Arq Bras Endocrinol Metabol. 2006 Aug;50(4):640–6.
UV radiation and cancer prevention: what is the evidence? Anticancer Res. 2006 Jul–Aug;26(4A):2723–7. Review.
The likely role of vitamin D from solar ultraviolet-B irradiance in increasing cancer survival. Anticancer Res. 2006 Jul–Aug;26(4A):2605–14.
Vitamin D and cancer. Anticancer Res. 2006 Jul–Aug;26(4A):2515–24. Review.
Associations between vitamin D, vitamin D receptor gene and the androgen receptor gene with colon and rectal cancer. Int J Cancer. 2006 Jun 15;118(12):3140–6.
Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med. 2006 Feb 16;354(7):684–96.
The Role of Vitamin D in Cancer Prevention. Am J Public Health. 2006 Feb;96(2):252–61. Review.
The epidemiology of vitamin D and colorectal cancer: recent findings. Curr Opin Gastroenterol. 2006 Jan;22(1):24–9. Review.
Upregulation of 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase by butyrate in Caco-2 cells. World J Gastroenterol. 2005 Dec 7;11(45):7136–41.
E-cadherin and vitamin D receptor regulation by Snail and Zeb1 in colon cancer: clinicopathological correlations. Hum Mol Genet. 2005 Nov 15;14(22):3361–70.
Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice. J Nutr. 2005 Oct;135(10):2350–4.
Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its Gemini analogs. J Steroid Biochem Mol Biol. 2005 Oct;97(1–2):111–20.
The Vitamin D endocrine system of the gut—its possible role in colorectal cancer prevention. J Steroid Biochem Mol Biol. 2005 Oct;97(1–2):121–8.
Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr. 2005 May;81(5):1147–54.
Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest. 2005 May;35(5):290–304. Review.
Intakes of calcium and vitamin D and risk of colorectal cancer in women. Am J Epidemiol. 2005 Apr 15;161(8):755–64.
Snail vs vitamin D receptor expression in colon cancer: therapeutics implications. British Journal of Cancer. 2005 March 15;92:985–989.
The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control. 2005 Mar;16(2):83–95. Review.
Vitamin D and the elderly. Clin Endocrinol (Oxf). 2005 Mar;62(3):265–81. Review.
The association of calcium and vitamin D with risk of colorectal adenomas. J Nutr. 2005 Feb;135(2):252–9.
Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1502–8.
Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2004 Apr;13(4):546–52.
Vitamin D3 from sunlight may improve the prognosis of breast-, colon- and prostate cancer (Norway). Cancer Causes Control. 2004 Mar;15(2):149–58.
A critical review of studies on vitamin D in relation to colorectal cancer. Nutr Cancer. 2004;48(2):115–23. Review.
Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial. J Natl Cancer Inst. 2003 Dec 3;95(23):1765–71.
Calcium, vitamin D, dairy products, and risk of colorectal cancer in the Cancer Prevention Study II Nutrition Cohort (United States). Cancer Causes Control. 2003 Feb;14(1):1–12.
Ecologic studies of solar UVB radiation and cancer mortality rates. Recent Results Cancer Res. 2003;164:371–7. Review.
Phytoestrogens regulate vitamin D metabolism in the mouse colon: relevance for colon tumor prevention and therapy. J Nutr. 2002 Nov;132(11 Suppl):3490S–3493S.
Vitamin D and systemic cancer: is this relevant to malignant melanoma? Br J Dermatol. 2002 Aug;147(2):197–213. Review.
Sunlight and mortality from breast, ovarian, colon, prostate, and non-melanoma skin cancer: a composite death certificate based case-control study. Occup Environ Med. 2002 Apr;59(4):257–62.
An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer. 2002 Mar 15;94(6):1867–75.
Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D. Cancer Epidemiol Biomarkers Prev. 2002 Jan;11(1):113–9.
Dietary calcium and vitamin D intake and risk of colorectal cancer: a prospective cohort study in women. Nutr Cancer. 2002;43(1):39–46.
25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression. Biochem Biophys Res Commun. 2001 Jul 27;285(4):1012–7.
25-hydroxyvitamin D-1alpha-hydroxylase in normal and malignant colon tissue. Lancet. 2001 May 26;357(9269):1673–4.
Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and adenomatous polyps of the distal colorectum. Cancer Epidemiol Biomarkers Prev. 2000 Oct;9(10):1059–65.
In colorectal carcinoma patients, serum vitamin D levels vary according to stage of the carcinoma. Cancer. 1999 Aug 1;86(3):391–7.
Studies of calcium in food supplements in humans. Ann N Y Acad Sci. 1999;889:128–37. Review.
Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Ann N Y Acad Sci. 1999;889:107–19. Review.
Intake of selected micronutrients and risk of colorectal cancer. Cancer Epidemiol Int J Cancer. 1997 Nov 14;73(4):525–30.
Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men. Cancer Causes Control. 1997 Jul;8(4):615–25.
Vitamin D metabolism in human colon adenocarcinoma-derived Caco-2 cells: expression of 25-hydroxyvitamin D3-1alpha-hydroxylase activity and regulation of side-chain metabolism. J Steroid Biochem Mol Biol. 1997 May;62(1):21–8.
Calcium, vitamin D, and the occurrence of colorectal cancer among women. J Natl Cancer Inst. 1996 Oct 2;88(19):1375–82.
Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol. 1996 May 1;143(9):907–17.
Sunlight—can it prevent as well as cause cancer? Cancer Res. 1995 Sep 15;55(18):4014–22. Review.
Interspecies comparative pathology of colorectal neoplasms: relevance for treatment. In Vivo. 1994 Nov–Dec;8(5):893–914.
Calcium, vitamin D, dairy foods, and the occurrence of colorectal adenomas among men and women in two prospective studies. Am J Epidemiol. 1994 Jan 1;139(1):16–29.
Relation of calcium, vitamin D, and dairy food intake to incidence of colon cancer among older women. The Iowa Women's Health Study. Am J Epidemiol. 1993 Jun 15;137(12):1302–17. Review.
Beneficial effects of sun exposure on cancer mortality. Prev Med. 1993 Jan;22(1):132–40. Review.
Colorectal cancer and solar radiation. Cancer Causes Control. 1992 Jan;3(1):95–9.
Multiple sclerosis and prostate cancer: what do their similar geographies suggest? Neuroepidemiology. 1992;11(4–6):244–54.
Can colon cancer incidence and death rates be reduced with calcium and vitamin D? Am J Clin Nutr. 1991 Jul;54(1 Suppl):193S–201S. Review.
Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet. 1989 Nov 18;2(8673):1176–8.
Acid haze air pollution and breast and colon cancer mortality in 20 Canadian cities. Can J Public Health. 1989 Mar–Apr;80(2):96–100.
Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet. 1985 Feb 9;1(8424):307–9.
Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol. 1980 Sep;9(3):227–31.

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