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Resveratrol and vitamin D: Do they work together?

Posted on: October 8, 2013   by  John Cannell, MD


Resveratrol is a naturally occurring stilbenoid, a type of phenol, produced by several plants, most notably the skin of red grapes. Much has been written about resveratrol, not all of it true.

However, one thing seems certain, vitamin D and resveratrol interact via an unknown mechanism, probably one that has to do with the vitamin D receptor. Let’s look at some of the research that implicates resveratrol and vitamin D: 

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3 Responses to Resveratrol and vitamin D: Do they work together?

  1. Gary

    Epigenetic is really fascinating area of research. Its clear already that resveratrol contributes to swithing on the genes involved in the NRF2 pathway that massively activate glutathione and super oxide dismutase. Forget about the latest fad for this juice or that berry this pathway is the real deal in terms of controlling oxidative stress. Curcumin can do the same and it wouldn’t surprise me if Vit D is involved aswell.

  2. Rita and Misty

    Gary, did you see this back in June? It speaks to Curcumin/D.


  3. Gary

    Yes its interesting the interactions between these phytochemicals and Vitamin D. There are two others that are also involved in the modulation of genes. Pterostilbene (blueberries) and sulphoraphane (brocolli) appear to influence these pathways even more strongly than Resveratrol.
    It wouldn’t surprise me if Vitamin D expression is also influenced by Pterostilbene and Sulphoraphane aswell.

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