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Research suggests vitamin D is a modifiable risk factor for miscarriage

Posted on: July 24, 2015   by  Vitamin D Council


A new study published in the American Journal of Clinical Nutrition has discovered that vitamin D status is a modifiable risk factor for miscarriage.

Miscarriages occur in about 12 to 20 percent of pregnancies, making it the most common adverse outcome of pregnancy. Vitamin D supplementation has been shown to reduce the risk of pregnancy complications, such as pre-eclampsia and gestational diabetes.

Researchers recently hypothesized that vitamin D status may also affect the risk of miscarriage. In order to test this hypothesis, the researchers measured the vitamin D levels of 1,683 pregnant women before gestational week 22.

They found that vitamin D levels less than 20 ng/ml were associated with over two times the risk for miscarriage during the first trimester in comparison to levels greater than or equal to 20 ng/ml. Vitamin D levels were not associated with an increased risk of miscarriage during the second-trimester.

The researchers concluded,

“We found an association between 25(OH)D and first- trimester miscarriages, suggesting vitamin D as a modifiable risk factor for miscarriage.”


Andersen L., et al. Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort. The American journal of clinical nutrition, 2015.

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