Reply To: I am a female in my early 40's. I have been taking 2,000 IU of Vitamin D3 for a couple of years. I recently started to use progesterone cream to treat pre-menopausal symptoms, and on the 3rd or 4th week I noticed that the skin on my trunk was getting flaky. Someone recommended me to increase the dose of Vitamin D3 and I increased to 5,000 IU a day. But the skin on my trunk got even more flaky and also it spread to my upper arms. It is slightly itchy but not very painful. There are some red rashes in some parts but other parts are just with flaky skin without redness. In addition, I am feeling very tired and sleepy. I am going to see a doctor next week for annual exam anyway, but I wonder if anyone has experienced the same.