Reply To: I have just been prescribed 50,000 iu of Vitamin D weekly to treat vitamin D deficiency. My 25-HD total is 6.9. Due to Irritable Bowel Syndrome and Barretts Esophagus, I take 80 mg of Prilosec daily. Due to Hyperactive thyroid with goiter, I take 200 mcg of synthroid – initial treatment was radioactive iodine. Only other meds I take is 10 mg of propranolol daily. This seems like an extremely high dose of vitamin d to take at once. Would taking a smaller amount each day be better? I also have a history of kidney stones. I am concerned that these high doses might cause more kidney stones or vitamin d toxicity. I am probably being overly cautious, but since vitamin d us fat soluble, I am concerned about taking this much in one dose. Haven't taken my first one yet.