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RCT: Vitamin D therapy shows no significant effect on resistant hypertension

Posted on: June 19, 2014   by  Amber Tovey


A new randomized controlled trial published in Journal of the American Heart Association found that vitamin D supplementation did not reduce blood pressure or left ventricular mass in patients with resistant hypertension.

Resistant hypertension is characterized by high blood pressure that still remains after lifestyle changes or after taking three or more anti-hypertensive medications. About 10-30% of patients with hypertension have resistant hypertension.

Resistant hypertension is associated with an increased risk for left ventricular hypertrophy (LVH). Left ventricular hypertrophy is the enlargement of the muscle tissue that makes up the heart’s main pumping chamber.

High blood pressure causes the heart to work harder when pumping blood. The increased workload causes the walls of the left ventricle to grow thicker and lose its elasticity, thus contributing to LVH. This can eventually lead to the heart not being able to pump blood anymore and increase the risk for certain cardiovascular diseases.

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