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RCT: Vitamin D reduced body fat mass in overweight women

Posted on: October 5, 2012   by  Vitamin D Council


A double-blind, randomized controlled trial published last month in Nutrition Journal reports that increasing vitamin D serum levels led to body fat mass reduction.

Dr Amin Salehpour and colleagues randomly assigned 18-50 year old overweight or obese women to the vitamin D3 group (1,000 IU/day) or the placebo group (25 μg/day lactose) for a 12 week intervention. Following the 3 month period, participant serum vitamin D status was measured as well as parathyroid hormone (PTH), body weight, body mass index, height, waist, and hips.

Mean vitamin D status at baseline was similar for the two groups, and increased significantly in the vitamin D group.

The researchers found that after the 12 week intervention, participants in the vitamin D group significantly reduced their body fat mass (p<0.001). The authors saw no significant change in body weight or waist circumference. The authors explain,

“…a modest fat mass reduction of 7% was associated with a significant increase of 25OHD levels by 103% and a significant decrease of PTH levels by 14%.”

The researchers call for further investigation into the link between 25(OH)D status and body composition.


Salehpour A, et al. A 12 week double blind randomized clinical trial of vitamin D3 supplementation on body fat mass in healthy overweight and obese women. Nutrition Journal. September 2012.

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