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RCT: Vitamin D and Prozac

Posted on: November 6, 2012   by  John Cannell, MD


Many readers have either taken a selective serotonin reuptake inhibiter (SSRI) like Prozac, Zoloft, Celexa, Lexapro, Luvox, or Paxil for one of the following:

  • depression
  • anxiety
  • obsessive-compulsive disorder
  • or for other indications
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2 Responses to RCT: Vitamin D and Prozac

  1. JBG

    “Iranian researchers. . .studied 42 patients with major depression, giving half of them 20 mg/day of Prozac and the other half 20 mg/day of Prozac plus 1,500 IU/day of vitamin D.”

    My immediate thought on reading that was, Why didn’t they have a third group that got 1,500 IU/day of vitamin D, period? Couldn’t it be that vitamin D by itself was doing most of the heavy lifting in the Prozac+D group?

    I agree that sunlight would likely be even better.

  2. [email protected]

    There are probably other or analogous examples of this effect. Sometimes a phase III trial does not produce results expected from phase II, and one could check to see if latitude or season had an effect in some cases. Probably detailed data would only be available to a CRO or a pharma company — or is that wrong? I don’t know what the FDA does with data after an approval determination is made, or if data is now submitted in machine readable form.

    The council could contact such sources and propose some statistical work. Such information would be worth a lot to pharmas spending large sums to test new drugs.

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