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RCT: High-dose vitamin D3 safe during pregnancy

Posted on: April 22, 2013   by  Kate Saley


A new randomized controlled trial shows once again, high-dose vitamin D during pregnancy is safe and effective at raising vitamin D blood levels for mother and newborn child. The recent randomized controlled trial was published in the Nutrition Journal.

Lead author Daniel Roth, MD, and colleagues administered vitamin D or placebo to pregnant women aged 18 to 25 years from Bangladesh. The supplementation started at some point during their third-trimester of pregnancy and lasted until birth. They randomly assigned 130 women to take 35,000 IU of vitamin D per week or to take a placebo pill. The women on average took supplements for about 10 weeks, or until delivery.

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4 Responses to RCT: High-dose vitamin D3 safe during pregnancy

  1. Rita and Misty

    Greetings Kate,

    This is a very well written article…a pleasure to read. Thank you.

    I think that the newborns from the vitamin D group may very well be healthier than the placebo group in years to come, in particular if the children from the placebo group never raise their vitamin d levels to optimal.

    It would be interesting to chart the health of the children from the Vitamin D group over many years…

    Regarding the vitamin D RDA for pregnant women:

    I think that RDA should be dropped and 25(OH)D level should be the only thing that counts!

    Everyone needs to maintain vitamin d serum levels of above 50 ng/ml for optimal health.

    IMO 🙂

  2. Rebecca Oshiro

    I agree with Rita’s comment about dropping the RDA and focusing on the 25(OH)D level, but unfortunately the policy wonks need generalized recommendations they can make to the public as a starting point.

  3. Rita and Misty

    I know…I work in a place that is literally paralyzed by policy..protocol..and bureaucracy….

    It is painful…

    Some days my head spins from the lunacy of it all, and all I can say is WOW…

    Thank goodness for the Vitamin D Council.

  4. Rebecca Oshiro

    Amen to that!

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