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RCT finds vitamin D2 supplementation has no effect on rheumatoid arthritis disease activity

Posted on: May 2, 2014   by  Will Hunter


A recent randomized, double-blinded, controlled study published in Journal of Clinical Rheumatology has found that supplementation with vitamin D2 has no effect on disease activity in rheumatoid arthritis. The researchers also found that vitamin D2 had a negative impact on symptoms.

Past epidemiological research on rheumatoid arthritis (RA) has shown that low vitamin D levels are associated with an increased risk of developing the autoimmune disease. There are also a few randomized controlled trials that have shown that increasing vitamin D levels decreases the severity of the disease. However, all of these RCTs used supplemental vitamin D3 as the intervention, not vitamin D2.

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2 Responses to RCT finds vitamin D2 supplementation has no effect on rheumatoid arthritis disease activity

  1. Rita and Misty

    It’s regretful that in the conclusion the authors did not explicitly state D2 appears to provide little improvement upon R.A. Now D3 will also be lumped into the “useless” category by those quoting the conclusion only…a perfect tool for those wishing to malign the health benefits of vitamin D. How sad. 🙁

  2. Ron Carmichael

    It is interesting that the designers required the subjects to use 65SPF sun block. The study is blocked by fee so I cannot delve completely into it, thus can’t determine what “vitamin D repletion” means, but given the parameters I can read, would bet it means getting the patient to what prudent, knowledgeable practitioners would consider a sub-therapeutic goal likely.
    It seems the intent was to evaluate the common but regrettable practice of physicians prescribing the D2 50,000 dose in lieu of the less lucrative D3 OTC product…not too very useful on the face of it.

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