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RCT finds vitamin D supplementation may improve neuromuscular motor skills in patients with HIV

Posted on: June 9, 2015   by  Amber Tovey


A recent randomized controlled trial published in the Journal of Musculoskeletal and Neuronal Interactions found that vitamin D supplementation improved neuromuscular motor skills in children and young adults with HIV.

More than 1.2 million people are affected by human immunodeficiency virus (HIV) infection in the United States, and about 1 in 7 people are unaware of their infection.

HIV weakens the immune system, allowing life-threatening opportunistic infections and cancers to thrive.

Vitamin D helps the immune system fight infections by increasing antimicrobial peptides and reducing inflammatory proteins called cytokines. Therefore, researchers have hypothesized a relationship between high vitamin D levels and improved immune system markers. This hypothesis was proven true by a research team from the Children’s Hospital of Philadelphia and the University of Pennsylvania.

HIV patients often experience deficiencies in muscular function. These deficiencies likely contribute to poor physical functioning and low quality of life in HIV patients. Studies have shown a relationship between vitamin D and neuromuscular motor skills. A past animal study showed that mice without vitamin D receptors have impaired neuromuscular motor performance in comparison to mice with vitamin D receptors.

The same research team that found a relationship between vitamin D status and immune system markers aimed to further their analysis on the effects of vitamin D supplementation in patients with HIV. In the current study, the researchers tested the hypothesis that daily vitamin D supplementation increases neuromuscular motor skills, jumping ability, muscular force and muscular strength. Neuromuscular motor skills refer to the body’s ability to send messages via nerve cells to control muscle movement.

The research team used the data from their prior randomized controlled trial to assess the effects of vitamin D supplementation on neuromuscular functions. The RCT enrolled 56 patients with HIV ages 9 to 25 years into the study. The patients were randomly divided into two groups: the placebo group and the vitamin D group. The patients in the vitamin D group received a daily vitamin D supplement of 7000 IU for 12 months; whereas the placebo group received a daily placebo pill for 12 months.

The researchers measured vitamin D status, neuromuscular motor skills, jumping ability and muscular strength at baseline, 3, 6 and 12 months.

Did vitamin D supplementation improve muscular function? Here is what the researchers found out:

  • The majority of patients had low vitamin D levels at baseline; 95% of participants were insufficient in vitamin D (< 32 ng/ml), 64% were deficient (<20 ng/ml) and 26% were severely deficient (<11 ng/ml).
  • The vitamin D group significantly increased their vitamin D levels by 12.1 ng/ml after 12 months (p < 0.001) compared to the placebo group. However, only 33% of the patients in the vitamin D group achieved vitamin D sufficiency.
  • After 12 months, vitamin D supplementation significantly improved neuromuscular motor skills compared to placebo group (p = 0.041).
  • There was no effect of supplementation on jump power, jump energy, muscular force or muscular strength outcomes in comparison to placebo.

The researchers concluded,

“In this randomized, double-blind, placebo-controlled trial of predominately African-American HIV-infected children and young adults, we observed a significant effect of vitD3 supplementation on neuromuscular motor skills versus placebo.”

They went on to note,

“Collectively these data are consistent with the hypothesis that vitD3 supplementation positively impacts clinical outcomes among HIV-infected children and young adults by improving neuromuscular motor skills and immune parameters.”

The study had several strengths to acknowledge. The researchers included a daily high dose of vitamin D supplementation (7000 IU) close to the Vitamin D Council’s recommendation of 5000 IU. Also, the study had a long duration of 12 months with high adherence to both the supplement and placebo. Lastly, most participants at baseline had insufficient vitamin D levels, allowing the study to illustrate the benefits of vitamin D supplementation.

There are also a few limitations to this study. This was a secondary analysis of muscle health outcomes, meaning that the initial study design was not focused on determining the effects of vitamin D supplementation on muscle function. The sample size was very small, which may have contributed to the study’s inability to identify significant differences in muscular power and muscular strength. Additionally, the study did not adjust their findings to account for physical activity, a potential confounding factor.

Larger randomized controlled trials are required to fully understand the benefits of vitamin D supplementation in patients with HIV.


Brown J., et al. The impact of vitamin D 3 supplementation on muscle function among HIV-infected children and young adults: a randomized controlled trial. Journal of Musculoskeletal and Neuronal Interactions, 2015.

3 Responses to RCT finds vitamin D supplementation may improve neuromuscular motor skills in patients with HIV

  1. Rebecca Oshiro

    If only 33% of the patients in the vitamin D group achieved vitamin D sufficiency after 7,000 IU per day I find myself wondering if this is due to either high body weight or a vitamin D supplement that did not contain what the label says. I highly doubt the majority of study participants had issues with intestinal absorption. I frequently administer vitamin D at 4 and 5,000 IU per day to family, friends, and clients and the blood work usually comes back in the 50-70 ng/mL range. It’s critical to use vitamin D supplements only from companies that regularly perform assays to ensure the contents match what the label claims. This includes, but is not limited to, Biotech, Costco, Kirkman Labs, Metagenics, and Vital Choice. If you have any doubts about your supplement, call the company and ask if they can supply you with the lab results for your particular batch. If they can’t do that, time to choose a vitamin D supplement from a company that can.

  2. William Hildreth

    I am taking coumadin, a blood thinner. Will this affect my vitamin D results?

  3. Adelle Sperling

    A recent Canadian study reveals that vitamin D requirements are definitely dependent on BMI (body mass index). Only a skinny person can get in the optimum range on 5000IU per day.

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