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Randomized controlled trial: Vitamin D supplements carry only slight risk in sarcoidosis

Posted on: October 29, 2013   by  Brant Cebulla


Vitamin D supplementation in sarcoidosis only carries a slight risk, according to a new randomized controlled trial out of New Zealand.

Sarcoidosis is one of the few diseases where you need to be cautious in supplementing with vitamin D and cautious in getting good amounts of sun exposure. The reason is that in sarcoidosis, 4–11% of the patients develop high serum calcium (hypercalcemia). In any hypercalcemic condition, caution is needed in supplementing with vitamin D. While supplementation doesn’t need to be avoided, it should be closely monitored by a health care professional, to make sure that it doesn’t further increase serum calcium levels.

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3 Responses to Randomized controlled trial: Vitamin D supplements carry only slight risk in sarcoidosis

  1. john9546

    I wonder if Vitamin K2 in addition to the Vitamin D3 would help control the calcium issues?

  2. Anh Phan

    When taking vitamin D, don’t forget the Magnesium. I have learned the hard lesion on vitamin D supplement. Other minerals also important too, but the Magnesium element is the second behind calcium our body need in quantity. Without Magnesium, our body can’t mineralize bone, that lead to over calcification, and many other problem. Our diet, and lifestyle has changed a lot , we don’t drink well water, don’t use sea salt, eat less seafood, which contain magnesium. Furthermore, soil depleted, cheap fertilizer has no magnesium or very little amount….Take a trip to garden center read all labels of fertilizers, you’ll see…I love vitamin D, it’s very important, just don’t forget the other nutrients, they need to be there to help vitamin D do its job properly.

  3. [email protected]

    I think the issue of hypercalcemia is misunderstood when it comes to vitamin D. The prefix “hyper” means too much with a negative connotation. I can appreciate it outside of the vitamin D experience and certainly there are many studies that support what is hyper and what is not. But vitamin D regulates calcium so as long as the increased calcium blood serum level is due to the increased vitamin D, the higher amount of calcium is not hyper. This was seen in the work done in East Germany when infants were given 600,000 iu of D at 3 months and then every 3 months until the age of 18 months. Blood serum levels were checked at 2 weeks after each dose. Sure enough, when the blood serum level of 25(OH)D got to 180 ng/mL, the level of calcium rose to what was considered hyper without D, but because the high calcium was due to the high D, there were no adverse effects. I think most doctors have a knee-jerk reaction to high calcium as they don’t know that when D is also high, the high calcium is not a danger.

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