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Information on the latest vitamin D news and research.

Find out more information on deficiency, supplementation, sun exposure, and how vitamin D relates to your health.

I have recently come a cross an article saying that taking Vit. D and Hydrochlortiazide can lead to liver problems. I have been on a prescription Vit. D2 50,000 units for 3 years. If I go off and take over the counter Vit. D my D levels drop. I have been on Hydrocholorthiazide fir 20 years. The last 3 years I have had constant elevated liver enzymes. Is there any more research on the correlation of the two and liver damage?


Asked by  lilac_woman5745386500 on June 28, 2016

  •  lilac_woman5745386500 on

    See title

    Answered by  lilac_woman5745386500 on

  • IAW
     IAW on

    So the only thing I can find is that “Diuretics in this class (such as hydrochlorothiazide) may increase the activity of vitamin D and can lead to inappropriately high calcium levels in the blood.” High calcium levels can lead to organ damage.
    Now in 2014 came this study at http://www.ncbi.nlm.nih.gov/pubmed/24657333. The VDC also reported about it here at https://www.vitamindcouncil.org/blog/is-it-safe-to-take-near-physiological-doses-of-vitamin-d-while-using-anti-hypertensive-medication/ but you can only view that one if you are a member. You can though, read the conclusion on the first link.
    So if you are on Hydrochlortiazide, and wanted to take vitamin D3, I would suspect that at least for awhile, your calcium levels should be checked to make sure this does not become a problem.
    Now if you take D2 as far as I know, only D2 levels will increase. (Do they report D2 and D3 levels when you get tested?) If you take D2, though, it will make your D3 levels decrease. So when you say “If I go off and take over the counter Vit. D my D levels drop” did you take the same amount of D3, 50,000 iu once a week? The equivalent DAILY amount to that 50,000iu is 7000 iu a day of D3. Now do not get me wrong and take the 7000iu without a doctor’s supervision. I was just trying to point out the equivalent and if you took a lot less than that, it would not be equal.
    The study listed above was done with a maximum of 4000iu a day.

    Answered by  IAW on