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New study finds vitamin D status is associated with levels of certain antioxidants

Posted on: June 13, 2014   by  Jeff Nicklas

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Recent research published in Clinical Endocrinology has found that vitamin D may reduce oxidative stress by influencing levels of certain antioxidants.

Oxidative stress occurs when there are high amounts of reactive oxygen species (ROS) in the body and the body is unable to neutralize them or repair the damage caused by these oxygen species. ROS are chemically active molecules that contain oxygen. Evidence suggests that oxidative stress is a contributor to chronic disease such as cardiovascular disease, type 2 diabetes, and chronic kidney disease.

Vitamin D is also associated with these chronic diseases in observational research and clinical research shows low vitamin D status increases the risk of developing these diseases.

If both vitamin D and oxidative stress play a role in the development of chronic disease, might there be an interaction between the two in which vitamin D may impact oxidative stress and modify disease risk?

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2 Responses to New study finds vitamin D status is associated with levels of certain antioxidants

  1. Ian

    “Higher vitamin D levels were significantly associated with lower concentrations of the antioxidant Cys”
    Do you think this is because the cysteine is being metabolised into GSH with higher levels of vitamin D???
    I assume these are serum levels not liver levels. I am not sure what the relationship is between serum levels of GSH and liver levels of GSH.

  2. Jeff Nicklas

    Ian,

    You bring up a very good point. It would make sense that Cys levels would be lower with higher vitamin D levels as the body makes GSH from Cys and vitamin D was positively associated with higher levels of GSH.

    It would be interesting to see a study explore the mechanisms with this metabolism to see if vitamin D plays a role in the body’s production of GSH from Cys.

    Best,
    Jeff

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