New study finds vitamin D does not reduce colds in asthma patients

Posted on: December 1, 2015   by  Vitamin D Council

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A recent randomized controlled trial (RCT) found that 28 weeks of vitamin D supplementation did not reduce the number or severity of colds in asthma patients. Clinical Advisor and EurekAlert covered the research in recent articles.

3 Responses to New study finds vitamin D does not reduce colds in asthma patients

  1. Ron Carmichael

    This study is fairly unique in that the investigators documented that their bolus + daily dosage of D3 achieved a specific 25(OH)D blood level of around 40 ng/ml. This level is probably about HALF of what asthmatics should approximate, in the presence of such a pathology as asthma, the body needs all the help this steroidal & endocrine/autocrine hormone can provide. There are studies found on the NCBI website, concerning the multiple positive effects D can have in diverse ways in asthma (NOT just preventing “flu”), such as these two (of many) studies would indicate:
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224414/
    and
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436923/
    It is interesting that this investigator does not call for larger population studies nor further evaluation, but pronounces the lack of apparent benefit of D in asthmatics for flu prophylaxsis in a manner some will take to mean that D has NO benefit at all. Rarely have I seen ANY investigator take such a unequivocal, adamant stand about his study’s outcome! If one is looking to make a headline and repeat postings in the newspapers, that is surely the way to go. On the other hand, if one is truly investigating the potential health effects of D, I would expect a broader summation with some acknowledgment that “while this study, limited to only 408 adult patients, would appear to not show a direct benefit in preventing flu, there remains a number of effects of proper cholecalciferol blood levels in asthmatics” for which further studies are called for, particularly in a pediatric population to correlate outcomes. And certainly any risks associated cessation of vitamin D supplementation should be carefully considered by the health practitioner.”

  2. Ron Carmichael

    The initial sentence in the study may have “set me up” to expect a better attention to conclusions: “Restoration of vitamin D sufficiency may reduce asthma exacerbations, events often associated with respiratory tract infections (RTIs) and cold symptoms.” Of course, there is so much more that could have been remarked upon regarding cellular mechanisms which D facilitates that are of benefit in asthmatics as well as non-asthmatics.

  3. rcbaker200@comcast.net

    Interesting that the study doesn’t acknowledge that other studies have found different conclusions. The 41 ng. level was measured at week 12, so the subjects had the effect of a 41 ng. level for only 16 weeks; we don’t know when in the 28 weeks the colds were experienced. Colds experience when levels were still low would have no significance to the conclusions of the study The study certainly had an unusual vigorous response to oral vitamin D. Out of the thousands of patients’ I’ve obtained 25-hydroxyvitamin D levels at baseline and 6 months, a number were still in their 30’s (ng.) at doses of 5000 units a day. Isn’t it odd this group had such a quick response to vitamin D and didn’t find the same thing that I did with a much higher number of subjects.(patients).. .

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