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New RCT determines dose-response to vitamin D in obese individuals

Posted on: August 21, 2014   by  Will Hunter


A randomized controlled trial looked at the dose-response relationship of vitamin D supplementation in obese participants after two months and found that it was significantly lower than healthy participants. In other words, obese participants required more vitamin D to reach similar levels as healthy participants.

The dose-response relationship describes the change in effect in an organism caused by differing levels of doses of substances after a certain amount of time. In this study, the researchers were looking at how a certain dose of supplemental vitamin D affected the serum vitamin D levels in obese individuals after two months.

Obesity is considered a risk factor for vitamin D deficiency. Obese individuals have consistently been found to have lower vitamin D levels and a greater likelihood of deficiency than non-obese individuals.

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1 Response to New RCT determines dose-response to vitamin D in obese individuals

  1. Ted

    Or you could look at a longer trial with a larger number of participants taking higher doses of Vitamin D.

    J Clin Endocrinol Metab. 2013 Dec;98(12):4845-51. doi: 10.1210/jc.2012-4103. Epub 2013 Sep 13.
    25-Hydroxyvitamin D response to graded vitamin D₃ supplementation among obese adults.
    Drincic A1, Fuller E, Heaney RP, Armas LA.
    Author information

    Guidelines have suggested that obese adults need 2 to 3 times more vitamin D than lean adults to treat vitamin D deficiency, but few studies have evaluated the vitamin D dose response in obese subjects.

    The purpose of this study was to characterize the pharmacokinetics of 25-hydroxyvitamin D [25(OH)D] response to 3 different doses of vitamin D₃ (cholecalciferol) in a group of obese subjects and to quantify the 25(OH)D dose-response relationship. DESIGN, SETTING, INTERVENTION, PATIENTS: This was a randomized, single-blind study of 3 doses of oral vitamin D₃ (1000, 5000, or 10,000 IU) given daily to 67 obese subjects for 21 weeks during the winter months.

    Serum 25(OH)D levels were measured at baseline and after vitamin D replacement, and 25(OH)D pharmacokinetic parameters were determined, fitting the 25(OH)D concentrations to an exponential model.

    Mean measured increments in 25(OH)D at week 21 were 12.4 ± 9.7 ng/mL in the 1000 IU/d group, 27.8 ± 10.2 ng/mL in the 5000 IU/d group, and 48.1 ± 19.6 ng/mL in the 10,000 IU/d group. Steady-state increments computed from the model were 20.6 ± 17.1, 35.2 ± 14.6, and 51.3 ± 22.0 ng/mL, respectively. There were no hypercalcuria or hypercalcemia events during the study.

    Our data show that in obese people, the 25(OH)D response to vitamin D₃ is directly related to dose and body size with ∼2.5 IU/kg required for every unit increment in 25(OH)D (nanograms per milliliter).

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