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Meta-analysis suggests vitamin D status range for greatest reduction in all-cause mortality

Posted on: August 18, 2014   by  Vitamin D Council


A meta-analysis published in American Journal of Public Health found that those with severe vitamin D deficiency had almost twice the mortality rate as those with vitamin D levels greater than 35 ng/ml.

Recent studies have shown an inverse relationship between vitamin D levels and mortality among patients with breast cancer, colorectal cancer, and other forms of cancers.

Recent analyses have examined and found relationships between vitamin D and all-cause mortality. However, vitamin D levels weren’t reported in the data so it hasn’t been shown what levels, if a specific cutoff exists, cause the greatest reduction in mortality.

Researchers recently combined the results of 32 observational studies to further evaluate this relationship.

Out of the 32 studies, 25 found a significant inverse relationship between all-cause mortality and vitamin D levels, meaning higher levels were related to decreased all-cause mortality.

The combined data from the 32 studies found that those with vitamin D levels below 10 ng/ml had nearly twice the mortalityrate as those with vitamin D levels above 35 ng/ml.

The researchers stated, “Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/ml rather than greater than 20 ng/ml.”

The researchers call for future meta-analyses on the relationship between vitamin D levels and all-cause mortality to combine the results of studies that are more similar to one another. In order for this to happen, further observational research needs to be done.


Garland C. et al. Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D. American Journal of Public Health, 2014.

3 Responses to Meta-analysis suggests vitamin D status range for greatest reduction in all-cause mortality

  1. Rita and Misty

    I’m uncertain as why we of the concrete jungle would require a lower 25(OH)D level than those currently living a hunter/gatherer lifestyle. Current hunter/gatherers have vitamin D blood levels of between 46 ng/ml and 104 ng/ml. So why would we require less than what nature has deemed optimal?

  2. Tom Weishaar

    Rita – From NHANES data, fewer than 25% of adult Americans have vitamin D levels above 30 ng/mL; fewer than 2% have levels above 45 ng/mL. So the reason studies like this one don’t report on higher levels is that there aren’t enough individuals with higher levels in the population to produce statistically significant conclusions. – Tom

  3. Magic

    My findings

    .I have had no sunburn since I have raised my numbers. . I only have a “beautiful” tan…for an 80 year old.not bad..lol..

    IMO the longer that the drug companies do their thing to mask the real problems that can be solved by the sun and D3 pills the more our country is going deeper into debt.

    The older I get, the more friends I see dying because they have taken the wrong advice. I have said it before, I take no prescription drugs and haven’t been sick for decades. I am not a doctor.but I am doing well.


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