A meta-analysis published in American Journal of Public Health found that those with severe vitamin D deficiency had almost twice the mortality rate as those with vitamin D levels greater than 35 ng/ml.
Recent studies have shown an inverse relationship between vitamin D levels and mortality among patients with breast cancer, colorectal cancer, and other forms of cancers.
Recent analyses have examined and found relationships between vitamin D and all-cause mortality. However, vitamin D levels weren’t reported in the data so it hasn’t been shown what levels, if a specific cutoff exists, cause the greatest reduction in mortality.
Researchers recently combined the results of 32 observational studies to further evaluate this relationship.
Out of the 32 studies, 25 found a significant inverse relationship between all-cause mortality and vitamin D levels, meaning higher levels were related to decreased all-cause mortality.
The combined data from the 32 studies found that those with vitamin D levels below 10 ng/ml had nearly twice the mortalityrate as those with vitamin D levels above 35 ng/ml.
The researchers stated, “Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/ml rather than greater than 20 ng/ml.”
The researchers call for future meta-analyses on the relationship between vitamin D levels and all-cause mortality to combine the results of studies that are more similar to one another. In order for this to happen, further observational research needs to be done.