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Meta-analysis discovers vitamin D deficiency may be a marker for glucose homeostasis in diabetic and non-diabetic individuals

Posted on: January 17, 2018   by  Vitamin D Council


Type 2 diabetes is one of the most common diseases worldwide, affecting up to 442 million individuals. A recent meta-analysis of observational studies from the journal, Nutrients, evaluated the relationship between vitamin D status and onset of type 2 diabetes.

Researchers included a total of 71 studies that evaluated 25(OH)D status in diabetic and nondiabetic individuals. All participants were over the age of 18 and came from 16 different countries across Europe, North America and Asia.

The researchers discovered that vitamin D status was inversely associated with type 2 diabetes (p < 0.0001). Additionally, it was discovered that vitamin D deficiency was correlated with fasting plasma glucose in non-diabetic patients as well as the diabetic patients (p < 0.0001).

The researchers concluded:

“This meta-analysis concludes that hypovitaminosis D is associated with increased risk of hyperglycemia both in diabetic and non-diabetic subjects.”

They continued,

“The increased inverse correlation between vitamin D status and glycemic level in diabetic versus non-diabetic subjects may suggest vitamin D as a marker of glucose homeostasis.”


Rafiq, S. Jeppesen, P. B. Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients, 2018.

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