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Mendelian randomization shows high vitamin D status leads to lower blood pressure

Posted on: June 30, 2014   by  Amber Tovey


A new study published in Lancet Diabetes and Endocrinology used Mendelian randomization to find that high vitamin D levels cause a decreased risk for hypertension.

While randomized controlled trials (RCT) are considered the gold standard for showing causation in clinical vitamin D research, the results can be skewed if the design of the study doesn’t meet important criteria.

To accurately determine whether vitamin D has an effect on a certain health condition, randomized controlled trials need to first recruit participants who have the condition and are deficient in vitamin D at baseline. The trial then needs to administer high, physiological doses for a sufficiently long duration.

Trials that meet these criteria are hard to conduct, but when these trials do meet the criteria, they result in strong findings that accurately depict vitamin D’s role in the health condition being studied.

Mendelian randomization is another method of research that can be used to help show causation.

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2 Responses to Mendelian randomization shows high vitamin D status leads to lower blood pressure

  1. [email protected]

    Very interesting article, but for readers like myself with no (or little) basic scientific knowledge of biology it would help our understanding and the education if the article was accompanied by a graphic description (back board) of the various steps. Am I asking the… impossible?

  2. Michael

    My son 43 has hard-to-lower hypertension. We have been taking Vitamin D 5,000 daily for over 5 years with no noticeable lowering effect. He actually takes a third drug since a couple of years ago: HCTZ 25mg, Lisinopril 30, Amlodipine 5mg.
    My hypertension, which evolved only after 60 years old, is easy to keep in the good range with just HCTZ 25 mg and Lisinopril 40 mg.
    When we do the test at the public sites, his blood pressure is 20 to 30 points above my reading. Yet at the doctor we are told our BP readings are about the same — go figure !!

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