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Low vitamin D levels in autistic children not due to decreased sun exposure or less dietary vitamin D

Posted on: December 19, 2016   by  John Cannell, MD

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It is well established that autistic children have lower vitamin D levels than typically developing children. This was recently confirmed by a meta-analysis of 11 studies looking at affected and control children’s 25(OH)D levels, finding significantly lower levels in autistic children.[i]

Critics suggest that diet and sun exposure are causing the anomaly in 25(OH)D levels. That is, it is possible that autistic children spend less time in the sun and/or eat a diet with less vitamin D.

Researchers in China did an interesting study to determine if in fact autistic children receive less sun exposure or consume less vitamin D in their diet.

F. Fahmy *, N. A. Sabri, M. H. El Hamamsy, M. El Sawi and O. K. Zaki. Vitamin D intake and sun exposure in autistic children. International Journal of Pharmaceutical Sciences and research. 2016, December, ISSN (Online): 0975-8232.

They compared the 25(OH)D levels of 42 children with autism to 40 typically developing children, finding the autistic children had 25(OH)D’s of 18.6 ng/ml compared to 28 ng/ml in the controls (P<0.001).

Much more interestingly, the researchers found that the two groups of children spent about the same number of minutes per week in the sun – 44 minutes for ASD and 47 minutes per week for the controls (P=0.559).

The same held true for oral intake, which was 164 IU /day (4 mcg/day) for the ASD children compared to 177 IU/day (4.4 mcg/day) for controls (P=0.42).

A few additional points: if you are a member of the lay public, which is more, 164 IU or 4 mcg? The answer is that they are the same amount, but vitamin D is cursed with the anachronistic IU to measure weight.

In a recent RCT conducted by SAAD et al, autistic children who were given a daily dosage of 300 IU/KG/day experienced a dramatic improvement in their autism symptoms. The children in the current study averaged 7 years of age and weighed 27 KG. If these children received the same supplementation dosage as provided in SAAD et al’s study (if you ignore the 5,000 IU/day upper limit), they would have received 8,100 IU/day. This sounds like a lot, but it is only 200 mcg.

I’m convinced most studies under dose because they use IU and not mcg to measure weight. Why not go to mcg instead of IU?  That would make 125 mcg instead of 5,000 IU, which is the dose that most adults need to receive daily in order to maintain healthy vitamin D levels.

 

Wang T, Shan L, Du L, Feng J, Xu Z, Staal WG, Jia F. Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis. Eur Child Adolesc Psychiatry. 2016 Apr;25(4):341-50.

2 Responses to Low vitamin D levels in autistic children not due to decreased sun exposure or less dietary vitamin D

  1. Ron Carmichael

    As the two values are considered identical (125mcg and 5,000iu), going to the mcg would be much less “alarming” through the simple appearance. During my counselling of patients in the pharmacy, when a patient reacts with insecurity to the suggested notion of taking “thousands” of units a day, often they nod with reassured acceptance when I explain it’s actually (only) the amount seen by a few grains of salt on the table. Vanishingly small amount spread over the entire body. Imagery is often everything in the patient’s mind. And for D, we are ALL patients.

  2. rkcannon@yahoo.com

    The way I remember it is 40,000 IU is only 1 mg (easier to relate to). And another way to look at it to make it less scary is that your skin generates 10,000 IU in full sun/swim suit in less that 1/2 hr. (whites).

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