VDC test kit slider

Low D associated with impaired hepatitis C treatment response

Posted on: October 11, 2012   by  Vitamin D Council


Study finds that people co-infected with HIV and hepatitis C who are vitamin D deficient are significantly less likely to have an early or sustained response to treatment than those with normal vitamin D status.

Past research has shown a high prevalence of vitamin D deficiency in people co-infected with HIV and Hepatitis C. Vitamin D acts as an antiviral, decreasing production of hepatitis C. In hepatitis infected patients (non-HIV), improved response rates to treatment have been observed in patients with sufficient vitamin D levels.

Austrian researchers investigated whether vitamin D was associated with this same response in co-infected people.

The researchers found that only a fifth of participants had sufficient vitamin D levels, defined as >30 ng/mL.

Rates of early virological response (EVR) to hepatitis C treatment differed with vitamin D levels. Ninety-two percent of participants with sufficient levels achieved EVR, while 68% achieved EVR with insufficient levels (10-30 ng/mL), and 47% participants with vitamin D deficiency (<10 ng/mL).

Achieving a sustained virological response (SRV; undetectable hepatitis C viral load 24 weeks after the completion of therapy) was also related to vitamin D status. SRV was achieved in 85% of participants with sufficient vitamin D levels, 60% with insufficiency, and 40% with deficiency.

The authors conclude:

“Vitamin D supplementation should be considered and evaluated prospectively in HIV/HCV coinfected patients receiving CHC treatment.”


Mandorfer M, et al. Low vitamin D levels are associated with impaired virologic response to PEGIFN+RBV therapy in HIV/HCV coinfected patients. AIDS. October 2012.

Carter M. Vitamin D deficiency associated with a poorer response to HCV treatment in HIV/HCV-co-infected patients. News. Nam aidsmap. October 2012.

Test Your Vitamin D Levels at Home!

Our in-home vitamin D test kit is easy, affordable, and an accurate way to find out your Vitamin D status.

order NOW

We need your help!

We're spreading awareness on Vitamin D Deficiency
Donate NOW
Latest Articles
What is the relationship between vitamin D and childhood UTIs?

A new study suggests vitamin D may protect against UTIs among children by upregulating their own naturally occurring antimicrobial peptides.

Weekly Newsletter

Our Sponsors

December 21st is DDAY. Click here to celebrate the day with us!