A recent study published in the Journal of Veterinary Internal Medicine evaluated the impact of cancer on vitamin D status in dogs.
Like humans, our furry companions are living longer than ever before, and thus experience an increased risk of developing cancer throughout their lifetime. In fact, dogs develop more types of cancer than all other companion animals.
Approximately 1 in 4 dogs are diagnosed with cancer each year. In addition, cancer is responsible for 47% of canine deaths, making this disease the leading cause of canine mortality.
Vitamin D plays a crucial role in cancer prevention and treatment. For example, vitamin D regulates cell differentiation and cell growth, two important components in cancer prevention. In addition, vitamin D can recognize when cells become dysfunctional and initiate cell apoptosis, or programmed cell death.
Research continues to support the role of vitamin D in cancer prevention and treatment among humans. In fact, low vitamin D status has been linked with cancer development, impaired treatment outcome and mortality in people.
Research evaluating the role of vitamin D status in cancer among dogs is in its infancy. One study suggested that dogs with vitamin D levels below 40 ng/ml (100 nmol/l) experienced a 3.9 fold increased risk of developing cancer. Research has also shown that dogs with cancer are more likely to be vitamin D deficient than their healthy counterparts.
Unfortunately, canine vitamin D metabolism differs from humans and is not well understood. Additionally, the reference range for vitamin D status in canines varies significantly, depending on the laboratory used. These factors make it difficult to draw conclusions based off the available data.
Therefore, researchers recently conducted a study to evaluate whether various forms of cancer may affect a dog’s vitamin D status. They also aimed to identify other factors that may impact vitamin D levels among healthy dogs and dogs with cancer.
All dogs included in the study were client owned. Those were considered healthy when they presented a normal medical history, physical exam, complete blood count and biochemical profile. Dogs with newly diagnosed cancer were evaluated at the Mona Campbell Centre for Animal Cancer at the Ontario Veterinary College’s Health Centre to confirm their diagnosis.
Those who received supplements containing calcium or vitamin D, received corticosteroid treatment within two weeks of enrollment, were less than 2 years old or were diagnosed with systemic or infectious diseases (aside from cancer) were excluded from the study. A total of 92 dogs met this criteria, and thus were included in the analysis. Of these dogs, 21 had osteosarcoma, 27 had lymphoma, 21 had mast cell tumors and 23 acted as healthy controls.
The researchers recorded the dog’s dietary vitamin D intake, breed, age, sex, neuter status, body weight, body condition score (BCS) and muscle condition score (MCS). All healthy dogs were followed for one year after enrollment to confirm sustained health. All dogs received a blood draw to measure ionized calcium and parathyroid levels. Ionized calcium is routinely measured to observe blood calcium levels. They also measured the following vitamin D metabolites:
Here is what the researchers found:
The researchers concluded,
“Results support a relationship between cancer and altered vitamin D metabolism in dogs, mediated by plasma ICa concentrations. The CYP24A1 activity and plasma [ionized calcium] should be measured in studies examining plasma 25(OH)D concentrations in dogs.”
Research continues to support the role of vitamin D status in canine health, showcasing the need for more clarity regarding vitamin D requirements for dogs, beyond prevention of rickets.
In order to determine whether vitamin D supplementation may prevent or help treat cancer in dogs, clinical trials are required.
Sturges, M. Is vitamin D metabolism altered in dogs with cancer? The Vitamin D Council Blog & Newsletter, 2017.