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In PCOS, new trial suggests very high-dose vitamin D supplementation has minimal effect on insulin sensitivity

Posted on: April 9, 2014   by  Jeff Nicklas


A new trial published in Reproductive Endocrinology has found that in polycystic ovary syndrome, vitamin D may have a minimal effect on insulin resistance and blood pressure, however further research is warranted.

Polycystic ovary syndrome (PCOS) is a complex condition that affects approximately 5% of women. The principal features of PCOS are lack of ovulation resulting in irregular periods, few or no periods, infertility, and ovaries with multiple cysts.

For reasons still not fully understood, insulin resistance is common in women with PCOS. Insulin resistance is a condition in which cells fail to respond to the action of the hormone insulin. This causes increased insulin production and leads to unhealthily high blood sugar and insulin levels.

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3 Responses to In PCOS, new trial suggests very high-dose vitamin D supplementation has minimal effect on insulin sensitivity

  1. Rita and Misty

    Jeff, I found your article to be very well written and completely unbiased. As someone who has suffered from PCOS, previously to correcting for vitamin D deficiency, I am grateful for your efforts.

    If it weren’t for the efforts of you and VDC staff to prepare these summarizes, I would most likely have missed this study. Honestly, I am so busy, that I only had a chance to read your summary, and not the actual study. Does it speak to 25(OH)D level achieved? I will share with you that my health only improved upon my 25(OH)D level being raised to 74 ng/ml.

    Jeff, may I make one suggestion? (I hope so, because I am going to make it anyways 😉 ) I think the title chosen for your article does your article an injustice. And the title chosen just might bias many readers against reading more than simply the title. Especially if the reader already has a negative bias towards nutritional items.

    Take a look:

    The title that was selected for your current article:

    “In PCOS, new trial suggests very high-dose vitamin D supplementation has minimal effect on insulin sensitivity”

    A much more positive and completely honest title for your current article:

    “In PCOS, new trial found trends toward vitamin D helping with insulin sensitivity”

    Which would encourage the reader to delve further into your information?

  2. IAW

    Rita, I agree with you on the whole “title” thing. The second one being better. Jeff just so you know you are not the first title we (I) think could have been written better.

    Rita the results were “Compared with placebo, vitamin D significantly increased 25-hydroxyvitamin D (mean [95% confidence interval] in vitamin D group 20.1 [15.7 to 24.5] ng/mL at baseline and 65.7 [52.3 to 79.2] ng/mL at 12 weeks.”

    I find the statement that “The placebo group experienced a significant increase in diastolic blood pressure” strange. If their D levels did not really change then why did their blood pressure change?

  3. Jeff Nicklas

    Thank you both for your suggestions, I always appreciate reading them. I feel the title is accurate and we haven’t noticed an effect on traffic to the blog.


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