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How high can we mega-dose?

Posted on: October 27, 2012   by  Brant Cebulla


Researchers may have uncovered what the highest one-time “mega-dose” of vitamin D you can administer, at least for bone health outcomes.

The study, published in the journal Calcified Tissue International, led by Professor Maurizio Rossini of the University of Verona, measured bone turnover markers in elderly patients after administering one-time mega-doses of vitamin D.

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4 Responses to How high can we mega-dose?

  1. kenmerrimanmd

    kind of like drinking 1000 glasses of water all at once to get a whole years worth

    probably won’t work

    seems to me that daily dosing works better and is easier for pts to comply with IMHO

  2. [email protected]

    There are 40 studies of vitamin D loading dose at VitaminDWiki

    Large doses are generally spread out over 1 to 2 months. http://www.vitamindwiki.com/tiki-index.php?page_id=326

    One equation is dose (IU)=40 x (75-serum 25-OHD(3))xbody weight. (kg and nmol)

    Converted ng and pounds

    Loading dose = 35 x (50 – serum 25-OHD(3)) x body weight.

    Reminder1: 2,000,000 IU of vitamin D every day for a week is toxic

    Reminder2: Mono-therapy is somewhat dangerous, should include cofactors


    Reminder3: Should confirm that the person is not allergic to vitamin D before having a loading dose. About 1 in 300 people get an allergic reaction – which is somewhat proportional to the size of the dose http://www.vitamindwiki.com/tiki-index.php?page_id=2433

  3. [email protected]

    The one time 500k iu dose of vitamin “D” that led to increased fracture, what vitamin “D” species? reference please.

    Until I read the title I had no clue as to whether or not this study was D3 or some other (marginally effective) analog.

    Brant, my recommendation; always be specific as to the D species and include all units.


  4. hlwelborn

    Wow. This is very interesting research. Thank you for sharing.

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