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High vitamin D levels may be a protective factor against nocturnal enuresis

Posted on: June 16, 2014   by  Vitamin D Council


A new study published in PLOS One has found that higher vitamin D levels may reduce the risk of developing nocturnal enuresis in children.

Nocturnal enuresis (NE) is also known as nighttime bedwetting in children over the age of five years old. Approximately five million children in the United States have NE.

One of the causes of NE is thought to be related to sleep disorders. While research hasn’t explored whether vitamin D plays any role in NE, there have been studies to show a relationship between vitamin D and sleep regulation.

Researchers out of China recently conducted a study to determine if vitamin D was related to NE.

They recruited 247 children aged five to seven years old with NE and measured their vitamin D levels. They wanted to see if vitamin D was related to NE and if having a certain vitamin D level affected their risk of developing NE.

They found that the prevalence of NE decreased as vitamin D levels increased. NE was prevalent in 7.3% of children with vitamin D levels above 20 ng/ml, while 17.5% of the children with vitamin D levels less than 20 ng/ml had NE.

“In the present study, a statistically significant association was found between serum [vitamin D] and NE,” the researchers concluded. “Our data revealed that children with lower [vitamin D] concentrations were at an increased risk of NE.”

With this being one of the first studies to find a relationship between vitamin D and NE, the researchers call for future studies to confirm this relationship and determine any mechanisms behind it.


Li, et al. Relationships between 25-Hydroxyvitamin D and Nocturnal Enuresis in Five- to Seven-Year-Old Children. PLOS One, 2014.

4 Responses to High vitamin D levels may be a protective factor against nocturnal enuresis

  1. IAW

    I would suppose if Vitamin D can eliminate night time bathroom trips for me and my husband, that it might do the same for the young.

  2. mbuck


    Are you supplementing, sunning, or both; and how much per individual weights?


  3. IAW

    To: Mbuck
    Please see my 2nd posting under “Meta-analysis: Vitamin D supplementation reduces specific inflammatory marker”. Hope that will answer your question. We supplement mostly but also get some sun. What I did fail to mention under that posting though, is that unfortunately we are both overweight.

  4. Michael

    My female cousin, who grew up about 400 miles from me, was a bed-wetter up to mid-elementary school. Everything failed to cure her till my uncle obtained a bed sheet with electric connections that set off an alarm whenever moistened by urine. The technique was to require my cousin to stand up sleepily moaning while the bed was changed. From many bed changes a night to eventually cured took a rather long time, but it did work. This was in the 1950’s.

    My cousin later in her early 20’s got Multiple Sclerosis and has been disabled by it for over 40 years. I do know that her mother was deathly (insanely, unbelievably) afraid of insects, so my cousin probably was unlikely to be outside much. I know that as a teenager she was a big fan of a disc-jocky on the radio in an era when people did not have carry-around transistors, indicating she probably spent a lot of time in the house listening to radio.

    Long story short: Another nail in the coffin of confidence in the medico-pharmaceutical quacks. When are people going to sue the sun screen makers for billions of dollars?

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