An introduction to Cardiovascular diseasesTreatment

Anyone considered at risk for or presenting with cardiovascular disease (CVD) should strongly consider increasing serum 25(OH)D levels to somewhere in the 40-80 ng/mL range. 

Serum 25(OH)D levels can be estimated based on a number of factors including oral intake and vitamin D production from solar UVB, but for certainty, serum 25(OH)D levels can be measured. 

Each 1000 IU/day of vitamin D3 increases serum 25(OH)D levels by 6-10 ng/mL1.  Doses as high as 50,000 IU/day can be taken for a few days to bring serum 25(OH)D levels up rapidly.

Page last edited: 04 May 2011


  1. Heaney, R. P. Davies, K. M. Chen, T. C. Holick, M. F. Barger-Lux, M. J. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003 Jan; 77 (1): 204-10.