Non-Hodgkin lymphomaVitamin D levels

Few studies have looked at the relationship between vitamin D in the blood and risk of NHL.

A study of Finnish smokers found an inverse correlation between 25(OH)D and incidence of NHL for cases diagnosed within seven years of blood draw, but not for longer times1

A recent pooled study from ten individual studies found no correlation between prediagnostic serum 25(OH)D and NHL incidence for ranges from 40 ng/mL2.

A case-control study in New York did not find any correlation between prediagnostic serum 25(OH)D levels, although the same study found an inverse correlation with respect to past but not present UV irradiance3. As mentioned, a reason for the discrepancy between ecological studies and observational studies is that the beneficial effect of vitamin D might occur both early and throughout life.

Page last edited: 03 May 2011


  1. Lim, U. Freedman, D. M. Hollis, B. W. Horst, R. L. Purdue, M. P. Chatterjee, N. Weinstein, S. J. Morton, L. M. Schatzkin, A. Virtamo, J. Linet, M. S. Hartge, P. Albanes, D. A prospective investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers. Int J Cancer. 2009 Feb 15; 124 (4): 979-86.
  2. Purdue, M. P. Freedman, D. M. Gapstur, S. M. Helzlsouer, K. J. Laden, F. Lim, U. Maskarinec, G. Rothman, N. Shu, X. O. Stevens, V. L. Zeleniuch-Jacquotte, A. Albanes, D. Bertrand, K. Weinstein, S. J. Yu, K. Irish, L. Horst, R. L. Hoffman-Bolton, J. Giovannucci, E. L. Kolonel, L. N. Snyder, K. Willett, W. Arslan, A. A. Hayes, R. B. Zheng, W. Xiang, Y. B. Hartge, P. Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol. 2010 Jul 1; 172 (1): 58-69.
  3. Kelly, J. L. Friedberg, J. W. Calvi, L. M. van Wijngaarden, E. Fisher, S. G. A case-control study of ultraviolet radiation exposure, vitamin D, and lymphoma risk in adults. Cancer Causes Control. 2010 Aug; 21 (8): 1265-75.