MelanomaVitamin D levels

Two studies found an inverse correlation between serum 25(OH)D levels and Breslow thickness1 2.

We found no studies that have reported significant correlations between serum 25(OH)D and incidence of melanoma. However, a recent paper found that women enrolled in the Woman’s Health Study who had a history of non-melanoma skin cancer and were taking 400 IU/d vitamin D plus 1500 mg/d calcium had a 57% (95% CI, 10-79%) reduced risk of developing melanoma3.

Page last edited: 18 July 2011


  1. Newton-Bishop, J. A. Beswick, S. Randerson-Moor, J. Chang, Y. M. Affleck, P. Elliott, F. Chan, M. Leake, S. Karpavicius, B. Haynes, S. Kukalizch, K. Whitaker, L. Jackson, S. Gerry, E. Nolan, C. Bertram, C. Marsden, J. Elder, D. E. Barrett, J. H. Bishop, D. T. Serum 25-hydroxyvitamin D3 levels are associated with breslow thickness at presentation and survival from melanoma. J Clin Oncol. 2009 Nov 10; 27 (32): 5439-44.
  2. Randerson-Moor, J. A. Taylor, J. C. Elliott, F. Chang, Y. M. Beswick, S. Kukalizch, K. Affleck, P. Leake, S. Haynes, S. Karpavicius, B. Marsden, J. Gerry, E. Bale, L. Bertram, C. Field, H. Barth, J. H. Silva Idos, S. Swerdlow, A. Kanetsky, P. A. Barrett, J. H. Bishop, D. T. Bishop, J. A. Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data. Eur J Cancer. 2009 Dec; 45 (18): 3271-81.
  3. Tang, J. Y. Fu, T. Leblanc, E. Manson, J. E. Feldman, D. Linos, E. Vitolins, M. Z. Zeitouni, N. C. Larson, J. Stefanick, M. L. Calcium Plus Vitamin D Supplementation and the Risk of Nonmelanoma and Melanoma Skin Cancer: Post Hoc Analyses of the Women's Health Initiative Randomized Controlled Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011 Jun 27;