LeukemiaVitamin D levels

The only paper we found that reported an inverse correlation between vitamin D and leukemia incidence was a nested case-control study from the Health Professionals Follow-up Study, which found a suggestive inverse association was observed for leukemias (RR = 0.44, 95% CI = 0.20 to 1.00) based on 82 cases1.

That study used a vitamin D index based on oral vitamin D intake and recreational exposure to solar UVB for 1000 men, then applied to all 50,000 men in the study. Significant inverse correlations were found for colorectal, esophageal, gastric, oral/pharyngeal, and pancreatic cancer, most of which have been reported as vitamin D-sensitive in other studies2 3.

Page last edited: 18 July 2011


  1. Giovannucci, E. Liu, Y. Rimm, E. B. Hollis, B. W. Fuchs, C. S. Stampfer, M. J. Willett, W. C. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst. 2006 Apr 5; 98 (7): 451-9.
  2. Grant, W. B. Garland, C. F. The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res. 2006 Jul-Aug; 26 (4A): 2687-99.
  3. Boscoe, F. P. Schymura, M. J. Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993-2002. BMC Cancer. 2006; 6264.