Endometrial cancerIntroduction

Keeping serum 25-hydroxyvitamin D levels around 40 ng/mL might reduce risk by 25% and increase survival after diagnosis.

Endometrial cancer is one of the approximately 20 vitamin D-sensitive types of cancer. The evidence comes largely from ecological (geographical) studies of endometrial cancer mortality rates.

Calcium intake also seems to reduce risk1 2 3. Use of oral contraceptives reduces risk4, likely through mechanisms including reduction in inflammation5

Based on analogy with results for breast and colorectal cancer, it seems that keeping serum 25-hydroxyvitamin D levels above 40 ng/mL would reduce risk by 25% and increase survival after diagnosis.

Page last edited: 22 August 2011


  1. Salazar-Martinez, E. Lazcano-Ponce, E. Sanchez-Zamorano, L. M. Gonzalez-Lira, G. Escudero, D. E. Los Rios P. Hernandez-Avila, M. Dietary factors and endometrial cancer risk. Results of a case-control study in Mexico. Int J Gynecol Cancer. 2005 Sep-Oct; 15 (5): 938-45.
  2. McCullough, M. L. Bandera, E. V. Moore, D. F. Kushi, L. H. Vitamin D and calcium intake in relation to risk of endometrial cancer: a systematic review of the literature. Prev Med. 2008 Apr; 46 (4): 298-302.
  3. Peterlik, M. Grant, W. B. Cross, H. S. Calcium, vitamin D and cancer. Anticancer Res. 2009 Sep; 29 (9): 3687-98.
  4. Rice, L. W. Hormone prevention strategies for breast, endometrial and ovarian cancers. Gynecol Oncol. 2010 Aug 1; 118 (2): 202-7.
  5. Maia, H. J. Casoy, J. Non-contraceptive health benefits of oral contraceptives. Eur J Contracept Reprod Health Care. 2008 Mar; 13 (1): 17-24.